Subtyping schizophrenia: A comparison of positive/negative and system-specific approaches.
Subtyping schizophrenia: A comparison of positive/negative and system-specific approaches.
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DOI：
10.1016/j.comppsych.2015.05.014
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发表时间：
2015-08
影响因子：
7.3
通讯作者：
F. Lang;S. Walther;K. Stegmayer;H. Anderson-Schmidt;T. Schulze;Thomas Becker;M. Jäger
中科院分区：
文献类型：
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作者：
F. Lang;S. Walther;K. Stegmayer;H. Anderson-Schmidt;T. Schulze;Thomas Becker;M. Jäger
背景精神分裂症是一种异质性疾病。多年来，已经提出了不同的方法来处理这种异质性的分类症状模式。方法采用阳性和阴性症状量表（PANSS）和伯尔尼精神病理学量表（BPS）进行分型，其中BPS由三个领域的分量表组成（语言，情感和运动行为）被假设与特定的大脑回路有关，评估100例精神分裂症谱系障碍住院患者的横断面精神病理学特征。然后，我们将参与者分为阳性/阴性和系统特定的亚组，以允许比较的两种approaches.ResultsThe分析显示PANSS阳性分项得分和BPS情感分项得分（r= 0.446，p <0.001）和PANSS阴性分项得分和BPS运动行为分项得分（r= 0.227，p = 0.023）之间的相关性。至于阳性和阴性亚型，更多的参与者被归类为阳性的语言主导亚型（30.3%）和情感主导亚型（30.3%），而更多的被归类为阴性的运动行为主导亚型（44.4%）。然而，大多数患者符合标准的混合subtype.ConclusionsThe结果表明，阳性/阴性和系统特异性的方法可以被视为互补。未来的研究应该检查这两种方法在纵向评估的精神病理症状，并将它们与定性现象学的方法。
BackgroundSchizophrenia is a heterogeneous disorder. Over the years, different approaches have been proposed to approach this heterogeneity by categorizing symptom patterns. The study aimed to compare positive/negative and system-specific approaches to subtyping.MethodsWe used the Positive and Negative Syndrome Scale (PANSS) and Bern Psychopathology Scale (BPS), which consists of subscales for three domains (language, affect and motor behavior) that are hypothesized to be related to specific brain circuits, to assess cross-sectional psychopathological characteristics in a sample of 100 inpatients with schizophrenia spectrum disorders. We then categorized participants into positive/negative and system-specific subgroups to allow comparisons of the two approaches.ResultsThe analyses revealed correlations between the PANSS positive subscore and the BPS affective subscore (r= .446,p< .001) and between the PANSS negative subscore and the BPS motor behavior subscore (r= .227,p= .023). As regards the positive and negative subtype, more participants were classified as positive in the language-dominant subtype (30.3%) and affect-dominant subtype (30.3%), whereas more were classified as negative in the motor behavior-dominant subtype (44.4%). However, most patients met the criteria for the mixed subtype.ConclusionsThe results suggest that the positive/negative and system-specific approaches can be regarded as complementary. Future studies should examine both approaches in a longitudinal assessment of psychopathological symptoms and link them with qualitative-phenomenological approaches.