DSM-5 changes and the prevalence of parent-reported autism spectrum symptoms in Fragile X syndrome.
DSM-5 changes and the prevalence of parent-reported autism spectrum symptoms in Fragile X syndrome.
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DSM-5 变化和家长报告的脆性 X 综合征中自闭症谱系症状的患病率。
DOI：
10.1007/s10803-014-2246-z
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发表时间：
2015
影响因子：
3.9
通讯作者：
BaileyJr,DonaldB
中科院分区：
文献类型：
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作者：
Wheeler,AnneC;Mussey,Joanna;Villagomez,Adrienne;Bishop,Ellen;Raspa,Melissa;Edwards,Anne;Bodfish,James;Bann,Carla;BaileyJr,DonaldB
我们使用调查方法评估了758名患有脆性X综合征(FXS)的患者(男性639名，女性119名)父母报告的自闭症症状。照顾者报告他们患有FXS的孩子是否被诊断出患有自闭症谱系障碍(ASD)，并根据与ASD诊断相关的可观察行为清单支持症状。根据DSM-IV-TRI和DSM-5标准对症状进行分类。根据照顾者认可的行为症状，38.7%的男性和24.7%的女性符合DSM-IV-T自闭症的诊断标准。根据DSM-5标准，符合ASD标准的男性(27.8%)和女性(11.3%)显著减少。虽然86.4%的男性和61.7%的女性符合DSM-5的限制和重复行为领域的标准，但只有29.4%的男性和13.0%的女性符合社交沟通和互动(SCI)领域的标准。将社交交流标准放宽一个症状计数会导致符合ASD标准的人数增加三倍，这表明亚阈值脊髓损伤症状对FXS患者在ASD诊断中的重要性。研究结果表明，基于新的DSM-5标准，ASD在FXS中的概念化方式可能存在重要差异。
We used survey methodology to assess parent-reported autism symptomology in 758 individuals (639 males; 119 females) with fragile X syndrome (FXS). Caregivers reported whether their child with FXS had been diagnosed with an autism spectrum disorder (ASD) and endorsed symptoms based on a list of observable behaviors related to ASD diagnoses. Symptom counts were categorized based onDSM-IV-TRandDSM-5criteria. Based on behavioral symptoms endorsed by caregivers, 38.7 % of males and 24.7 % of females met criteria forDSM-IV-TRdiagnosis of autistic disorder. Significantly fewer males (27.8 %) and females (11.3 %) met criteria for ASD based onDSM-5criteria. Although 86.4 % of males and 61.7 % of females met criteria for the restricted and repetitive behavior domain for DSM-5, only 29.4 % of males and 13.0 % of females met criteria for the social communication and interaction (SCI) domain. Relaxing the social communication criteria by one symptom count led to a threefold increase in those meeting criteria for ASD, suggesting the importance of subthreshold SCI symptoms for individuals with FXS in ASD diagnoses. Findings suggest important differences in the way ASD may be conceptualized in FXS based on the newDSM-5criteria.