Bradykinin contribution to renal blood flow effect of angiotensin converting enzyme inhibitor in the conscious sodium-restricted dog.
Bradykinin contribution to renal blood flow effect of angiotensin converting enzyme inhibitor in the conscious sodium-restricted dog.
复制标题
缓激肽对清醒钠限制狗中血管紧张素转换酶抑制剂肾血流影响的贡献。
DOI：
10.1161/01.res.66.1.234
复制
发表时间：
1990
影响因子：
20.1
通讯作者：
Stewart,JM
中科院分区：
文献类型：
--
作者：
Zimmerman,BG;Raich,PC;Vavrek,RJ;Stewart,JM
我们研究了在钠剥夺犬中，血管紧张素转换酶抑制剂依那普利拉对肾脏血流动力学影响的相对作用，即肾素-血管紧张素系统阻滞和缓激肽增强。6只清醒的狗被用于监测血压（BP）和肾血流量（RBF），分为5组实验。在第1组中，仅给予依那普利拉，其使BP降低了-24 +/- 3 mm Hg，并使RBF增加了135 +/- 15 ml/min。在持续静脉输注saralasin期间（第2组），依那普利拉使BP降低了-7 +/- 3 mm Hg，并使RBF增加了84 +/- 7 ml/min（Δ BP和Δ RBF，通过方差分析，与第1组相比，p <0.01）。在肾内动脉持续输注saralasin期间（第3组），依那普利拉给药后BP和RBF的变化分别为-10 +/- 3 mm Hg和69 +/- 12 ml/min，这些结果与第2组无差异。静脉或肾动脉灌注saralasin可轻度降低BP，增加RBF。在静脉输注特异性缓激肽拮抗剂D-Arg-Arg-Pro-Hyp-Gly-Thi-Ser-D-Phe-Thi-Arg.TFA（B5630）（第4组）的情况下，依那普利拉使BP降低-28 +/- 4 mm Hg，使RBF增加82 +/- 24 ml/min（Δ RBF，p小于0.01，与第1组相比）。（250字处删节）
We examined the relative contribution of renin-angiotensin system blockade and bradykinin potentiation to the renal hemodynamic effect of the angiotensin converting enzyme inhibitor enalaprilat in sodium-deprived dogs. Six conscious dogs instrumented for monitoring of blood pressure (BP) and renal blood flow (RBF) were employed in five groups of experiments. In group 1, enalaprilat alone was administered, and it decreased BP by -24 +/- 3 mm Hg and increased RBF by 135 +/- 15 ml/min. During a constant intravenous infusion of saralasin (group 2), enalaprilat decreased BP by -7 +/- 3 mm Hg and increased RBF by 84 +/- 7 ml/min (delta BP and delta RBF, p less than 0.01 vs. group 1 by analysis of variance). During a constant intrarenal arterial infusion of saralasin (group 3), the respective changes in BP and RBF after enalaprilat were -10 +/- 3 mm Hg and 69 +/- 12 ml/min, and these results did not differ from those of group 2. The infusion of saralasin intravenously or intrarenal arterially decreased BP slightly and increased RBF. In the presence of an intravenous infusion of a specific bradykinin antagonist, D-Arg-Arg-Pro-Hyp-Gly-Thi-Ser-D-Phe-Thi-Arg.TFA (B5630) (group 4), enalaprilat decreased BP by -28 +/- 4 mm Hg and increased RBF by 82 +/- 24 ml/min (delta RBF, p less than 0.01 vs. group 1).(ABSTRACT TRUNCATED AT 250 WORDS)