Mass selective ion transfer and accumulation in ion trap arrays.
Mass selective ion transfer and accumulation in ion trap arrays.
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DOI：
10.1021/ac502583b
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发表时间：
2014-10
影响因子：
7.4
通讯作者：
Yuzhuo Wang;Xiaohua Zhang;Yanbing Zhai;You Jiang;Xiang Fang;Mingfei Zhou;Yulin Deng;W. Xu
中科院分区：
文献类型：
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作者：
Yuzhuo Wang;Xiaohua Zhang;Yanbing Zhai;You Jiang;Xiang Fang;Mingfei Zhou;Yulin Deng;W. Xu
阐述了四极离子阱阵列中质量选择性离子迁移和积累的概念和方法。已经对两组离子阱阵列进行了概念验证实验：（1）具有轴向离子喷射的线性离子阱加上具有径向离子喷射的线性离子阱;（2）具有轴向离子喷射的线性离子阱加上具有轴向离子喷射的线性离子阱。在两组离子阱阵列中，在第一离子阱中捕获的离子可以被质量选择性地转移并累积到第二离子阱中，同时保持其他离子保留在第一离子阱中。已经实现并测试了不同的操作模式，包括转移所有离子、选定质量范围内的离子、质荷比为1的离子以及随机选择的离子。离子迁移的单位质量分辨率和离子迁移效率达到90%以上。一种新的串联质谱方案，用于分析多个前体离子在一个单一的样品注射已被证明，这将提高仪器的占空比和样品利用率（特别是对于非常有限的样品），潜在地促进应用，如单细胞分析，并提高电子转移解离效率。
The concept and method for mass selective ion transfer and accumulation within quadrupole ion trap arrays have been demonstrated. Proof-of-concept experiments have been performed on two sets of ion trap arrays: (1) a linear ion trap with axial ion ejection plus a linear ion trap with radial ion ejection; (2) a linear ion trap with axial ion ejection plus a linear ion trap with axial ion ejection. In both sets of ion trap arrays, ions trapped in the first ion trap could be mass selectively transferred and accumulated into the second ion trap, while keeping other ions reserved in the first ion trap. Different operating modes have been implemented and tested, including transferring all ions, ions within a selected mass range, ions with a mass-to-charge ratio of 1, and randomly selected ions. Unit mass resolution for ion transfer and ∼90% ion transfer efficiency has been achieved. A new tandem mass spectrometry scheme for analyzing multiple precursor ions in a single sample injection has been demonstrated, which would improve instrument duty cycle and sample utilization rate (especially for very limited samples), potentially facilitate applications like single cell analyses, and improve electron transfer dissociation efficiency.