Melphalan Culprit or Confounder in Acute Encephalopathy during Autologous Hematopoietic Stem Cell Transplantation?
Melphalan Culprit or Confounder in Acute Encephalopathy during Autologous Hematopoietic Stem Cell Transplantation?
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DOI：
10.1155/2012/942795
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发表时间：
2012-05
影响因子：
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通讯作者：
Diógenes Alayón-Laguer;M. Alsina;J. Ochoa-Bayona;E. Ayala
中科院分区：
文献类型：
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作者：
Diógenes Alayón-Laguer;M. Alsina;J. Ochoa-Bayona;E. Ayala
我们报告一例女性Durie-Salmon期3A/ISS期I期IgG kappa多发性骨髓瘤（MM）患者在大剂量melphalan和造血干细胞移植（HSCT）后发生脑病。脑病最常见的病因，如感染、麻醉药物、代谢电解质紊乱、中风和中枢神经系统（CNS）出血被排除。病人自然地从精神状态的改变中恢复过来。考虑了melphalin诱导的脑病、危重状态谵妄和高细胞分裂血症诱导的脑病的可能性。
We report a case of a female patient with Durie-Salmon stage 3A/ISS stage I IgG kappa multiple myeloma (MM) who developed encephalopathy after high-dose melphalan and hematopoietic stem cell transplant (HSCT). The most common etiologies for encephalopathy such as infection, narcotic medications, metabolic-electrolyte disturbance, stroke, and central nervous system (CNS) hemorrhages were ruled out. The patient recovered from the altered mental status spontaneously. The possibilities of melphalan-induced encephalopathy versus critical-state delirium versus hypercytokinemia induce encephalopathy were contemplated.