Temporally graded requirement for protein synthesis following memory reactivation
Temporally graded requirement for protein synthesis following memory reactivation
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DOI：
10.1016/s0896-6273(02)00976-5
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发表时间：
2002-10-24
期刊：
影响因子：
16.2
通讯作者：
Alberini, CM
中科院分区：
文献类型：
--
作者：
Milekic, MH;Alberini, CM
对新信息的学习通过一个被称为巩固的过程转化为长期记忆，这需要蛋白质合成。经典理论认为，一旦巩固，记忆对破坏就不敏感了。然而，对蛋白质合成抑制剂不敏感的旧记忆如果被召回(重新激活)，可能会变得脆弱。这些发现导致了一种新的假设，即当旧的记忆被重新激活时，它再次变得不稳定，类似于新形成的记忆，需要一个重新巩固的过程才能保持。在这里，我们表明，只有当记忆是最近的时候，重新激活的记忆对蛋白质合成的要求才是明显的。事实上，记忆易损性随着原始训练和回忆之间时间的增加而减少。
Learning of new information is transformed into long-lasting memory through a process known as consolidation, which requires protein synthesis. Classical theory held that once consolidated, memory was insensitive to disruption. However, old memories that are insensitive to protein synthesis inhibitors can become vulnerable if they are recalled (reactivated). These findings led to a new hypothesis that when an old memory is reactivated, it again becomes labile and, similar to a newly formed memory, requires a process of reconsolidation in order to be maintained. Here, we show that the requirement for protein synthesis of a reactivated memory is evident only when the memory is recent. In fact, memory vulnerability decreases as the time between the original training and the recall increases.