Sonography of the skin at 100 MHz enables in vivo visualization of stratum corneum and viable epidermis in palmar skin and psoriatic plaques.
Sonography of the skin at 100 MHz enables in vivo visualization of stratum corneum and viable epidermis in palmar skin and psoriatic plaques.
复制标题
100 MHz 的皮肤超声检查可实现手掌皮肤和银屑病斑块中角质层和活表皮的体内可视化。
DOI：
--
复制
发表时间：
1999
影响因子：
6.5
通讯作者：
Helmut Ermert
中科院分区：
文献类型：
--
作者：
S. Gammal;C. Gammal;K. Kaspar;C. Pieck;Peter J. Altmeyer;Michael Vogt;Helmut Ermert
用于皮肤成像的20-25 MHz超声单元的主要缺点是其有限的分辨率。我们使用的传感器中心频率为95 MHz，轴向分辨率为8.5 μ m，横向分辨率为27 μ m-与20 MHz相比几乎增加了10倍。通过一种新的扫描技术，我们达到了3.2毫米的景深。我们检查了正常的手掌皮肤，正常无毛皮肤的腹部，上背部，小腿和背前臂，和35个寻常型银屑病病变。从11个银屑病斑块活检采取与超声波图的相关性。在正常手掌皮肤中，角质层被表示为皮肤进入回波下方的回波差带，被回声线圈穿过，其对应于外分泌汗腺导管。在封闭应用凡士林后，该带的厚度显著增加。其下边界由回声线限定，代表角质层/Malpighii层界面。在下面，可见第二条回声差带，对应于有活力的表皮加上乳头状真皮，与网状真皮的散射回声反射相邻。在无毛皮肤中也可见此带;然而，不能检测到角质层。在银屑病皮损中，增厚的角质层出现回声，凡士林涂抹后，回声密度降低。下图，棘层表皮和炎症浸润的真皮显示为回声差带。该带的超声厚度与棘皮症和浸润真皮的组织学厚度之间有很好的相关性。我们的研究结果表明，100 MHz超声是一个有价值的工具，在体内检查的上层皮肤。
A main drawback of 20-25 MHz ultrasound units for skin imaging is their limited resolution. We used a transducer with a center frequency of 95 MHz and a resolution of 8.5 microm axially and 27 microm laterally - an almost 10-fold increase compared with 20 MHz. By means of a new scanning technology we reached a depth of field of 3.2 mm. We examined normal palmar skin, normal glabrous skin on the abdomen, the upper back, the calf and the dorsal forearm, and 35 lesions of psoriasis vulgaris. From 11 psoriatic plaques biopsies were taken for correlation with the sonograms. In normal palmar skin, the horny layer is represented as an echopoor band below the skin entry echo, traversed by echorich coils, which correspond to eccrine sweat gland ducts. The thickness of this band significantly increases after occlusive application of petrolatum. Its lower border is defined by an echorich line, representing the stratum corneum/stratum Malpighii-interface. Underneath, a second echopoor band is visible, which corresponds to the viable epidermis plus the papillary dermis, bordered by the scattered echo reflexes of the reticular dermis. This band is also visible in glabrous skin; however, the stratum corneum cannot be detected. In psoriatic lesions, the thickened horny layer appears echorich; after application of petrolatum, its echodensity decreases. Below, the acanthotic epidermis plus the dermis with the inflammatory infiltrate are represented as an echopoor band. There is an excellent correlation between the sonometric thickness of this band and the histometric thickness of the acanthosis plus the infiltrated dermis. Our results show that 100 MHz sonography is a valuable tool for in vivo examination of the upper skin layers.