Cocaine and methamphetamine produce different patterns of subjective and cardiovascular effects
Cocaine and methamphetamine produce different patterns of subjective and cardiovascular effects
复制标题
DOI：
10.1016/j.pbb.2005.07.012
复制
发表时间：
2005-09-01
影响因子：
3.6
通讯作者：
Nestor, L
中科院分区：
文献类型：
--
作者：
Newton, TF;De La Garza, R;Nestor, L
可卡因和甲基苯丙胺的兴奋作用是通过脑单胺突触浓度的变化来调节的；然而，这两种药物通过不同的机制改变单胺水平。本研究考察了调查性使用可卡因或甲基苯丙胺所产生的主观和心血管反应，以检验主观和心血管反应的发生和模式。受试者包括14名未接受治疗寻求可卡因依赖的志愿者和11名未接受治疗寻求甲基苯丙胺依赖的志愿者。作为正在进行的研究的一部分，可卡因和甲基苯丙胺受试者分别接受可卡因(40毫克，静脉注射)或甲基苯丙胺(30毫克，静脉注射)。分别在30min和60min内评估主观反应和心血管反应。数据显示，在所有主观效应和心血管效应方面，组内差异显著(p
The stimulant effects of cocaine and methamphetamine are mediated by changes in synaptic concentrations of brain monoamines; however, the drugs alter monoamine levels via different mechanisms. This study examined the subjective and cardiovascular responses produced by investigational administration of cocaine or methamphetamine, in order to examine the onset and patterns of subjective and cardiovascular responses. Subjects included 14 non-treatment seeking cocaine-dependent and 11 non-treatment seeking methamphetamine-dependent volunteers. As part of ongoing research studies, cocaine and methamphetamine subjects received cocaine (40 mg, IV) or methamphetamine (30 mg, IV), respectively. Subjective and cardiovascular responses were assessed for 30 min and 60 min, respectively. The data reveal significant within groups differences for all subjective effects and cardiovascular effects (p