The role of Hedgehog signaling in fibrogenic liver repair.
The role of Hedgehog signaling in fibrogenic liver repair.
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DOI：
10.1016/j.biocel.2010.10.015
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发表时间：
2011-02
影响因子：
4
通讯作者：
Diehl, Anna Mae
中科院分区：
文献类型：
--
作者：
Choi, Steve S.;Omenetti, Alessia;Syn, Wing-Kin;Diehl, Anna Mae
与许多组织一样，成年肝脏的修复涉及多种不同细胞类型的协同反应。在成年肝脏中，成纤维细胞、胆管细胞、炎症细胞和祖细胞都参与了这一过程。我们的研究表明，这些细胞的命运至少在一定程度上是由音猬因子（Hedgehog）决定的，音猬因子是一种胎儿形态发生途径，曾经被认为主要在胚胎发生期间活跃。对受伤的成年人类和啮齿动物肝脏的研究表明，与损伤相关的音猬因子途径的激活调节了修复的几个重要方面，包括肝祖细胞群的生长、肌成纤维细胞在肝脏的积聚、与修复相关的炎症反应、血管重塑、肝纤维化和肝癌发生。这些发现将音猬因子途径确定为生物标志物开发和治疗干预的一个潜在重要靶点，并强调需要进一步研究以增进对该途径如何受调节成年肝脏修复的其他信号调控以及如何与其相互作用的了解。
Repair of adult liver, like many tissues, involves the coordinated response of a number of different cell types. In adult livers, fibroblastic cells, ductular cells, inflammatory cells, and progenitor cells contribute to this process. Our studies demonstrate that the fates of such cells are dictated, at least in part, by Hedgehog, a fetal morphogenic pathway that was once thought to be active mainly during embryogenesis. Studies of injured adult human and rodent livers demonstrate that injury-related activation of the Hedgehog pathway modulates several important aspects of repair, including the growth of hepatic progenitor populations, hepatic accumulation of myofibroblasts, repair-related inflammatory responses, vascular remodeling, liver fibrosis and hepatocarcinogenesis. These findings identify the Hedgehog pathway as a potentially important target for biomarker development and therapeutic manipulation, and emphasize the need for further research to advance knowledge about how this pathway is regulated by and interacts with other signals that regulate adult liver repair.
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DOI：
10.1152/ajpgi.00292.2009
发表时间：
2009-12-01
影响因子：
4.5
作者：
Choi, Steve S.;Omenetti, Alessia;Diehl, Anna Mae
通讯作者：
Diehl, Anna Mae
影响因子：
64.8
作者：
Chuang, PT;McMahon, AP
通讯作者：
McMahon, AP
DOI：
10.1073/pnas.95.23.13630
发表时间：
1998-11-10
影响因子：
11.1
作者：
Carpenter, D;Stone, DM;de Sauvage, FJ
通讯作者：
de Sauvage, FJ
影响因子：
25.7
作者：
Falkowski, O;An, HJ;Theise, ND
通讯作者：
Theise, ND
影响因子：
2.7
作者：
Bort, R;Signore, M;Zaret, KS
通讯作者：
Zaret, KS