Fratricide among CD8+ T lymphocytes naturally infected with human T cell lymphotropic virus type I
Fratricide among CD8+ T lymphocytes naturally infected with human T cell lymphotropic virus type I
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DOI：
10.1016/s1074-7613(00)00065-0
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发表时间：
2000-11-01
期刊：
影响因子：
32.4
通讯作者：
Bangham, CRM
中科院分区：
文献类型：
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作者：
Hanon, E;Stinchcombe, JC;Bangham, CRM
人类嗜T淋巴细胞病毒I型（HTLV-I）在体内的感染和基因表达被认为仅限于CD 4（+）T淋巴细胞。我们在这里显示，在自然HTLV-I感染，一个显着比例的CD 8（+）T淋巴细胞被HTLV-I感染。有趣的是，HTLV-I特异性而非EB病毒特异性CD 8（+）T淋巴细胞被感染。此外，自然感染的CD 8（+）T淋巴细胞中的HTLV-I蛋白表达使它们容易受到自体HTLVI特异性CD 8 + T淋巴细胞介导的自相残杀。病毒特异性CTL之间的相互残杀可能会削弱HTLV-I和其他嗜淋巴细胞病毒的免疫控制。
Infection and gene expression by the human T lymphotropic virus type I (HTLV-I) in vivo have been thought to be confined to CD4(+) T lymphocytes. We show here that, in natural HTLV-I infection, a significant proportion of CD8(+) T lymphocytes are infected by HTLV-I. Interestingly, HTLV-I-specific but not Epstein-Barr virus-specific CD8(+) T lymphocytes were shown to be infected. Furthermore, HTLV-I protein expression in naturally infected CD8(+) T lymphocytes renders them susceptible to fratricide mediated by autologous HTLVI-specific CD8+ T lymphocytes. Fratricide among virus-specific CTLs could impair the immune control of HTLV-I and possibly other lymphotropic viruses.