Convergent assembly of polycyclic ethers via acyl radical addition to unactivated enol ether.
Convergent assembly of polycyclic ethers via acyl radical addition to unactivated enol ether.
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DOI：
10.1021/ol062349i
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发表时间：
2006-11
期刊：
影响因子：
5.2
通讯作者：
M. Inoue;Yuuki Ishihara;Shuji Yamashita;M. Hirama*
中科院分区：
文献类型：
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作者：
M. Inoue;Yuuki Ishihara;Shuji Yamashita;M. Hirama*
提出了一种新的6/6-和6/7-稠醚环体系的聚合策略。在我们的方法中的关键特征包括Ag+-促进容易形成化学不稳定的烯醇醚从O，S-缩醛和加成的酰基自由基未活化的烯醇醚环化的六元或七元醚环。[反应：见正文]
A new convergent strategy for assembling 6/6- and 6/7-fused ether ring systems was developed. The key features in our method include Ag+-promoted facile formation of chemically labile enol ether from O,S-acetal and addition of an acyl radical to unactivated enol ether to cyclize a six- or seven-membered ether ring. [reaction: see text]