Decomposition-based quantitative electromyography in the evaluation of muscular dystrophy severity
Decomposition-based quantitative electromyography in the evaluation of muscular dystrophy severity
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DOI：
10.1002/mus.22341
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发表时间：
2012-04-01
期刊：
影响因子：
3.4
通讯作者：
Doherty, Timothy J.
中科院分区：
文献类型：
--
作者：
Derry, Kendra L.;Venance, Shannon L.;Doherty, Timothy J.
简介：肌电图在肌病的诊断中是有用的，但其在确定疾病严重程度方面的效用需要进一步研究。在这项研究中，我们的目的是确定是否分解为基础的定量肌电图（DQEMG）可以指示参与肌肉营养不良（MD）患者的队列的严重程度。研究方法：15例面肩肱型（FSHD）、肢带型（LGMD）和Becker型（BMD）肌营养不良症患者和7例健康对照者参加了这项调查。膝关节伸肌等长力量区分更严重和不太严重的MD组。股外侧肌（VL），肱二头肌（BB），胫骨前肌（TA）肌肉群进行了研究，使用DQEMG。结果如下：与对照组相比，MD组所有肌肉的平均运动单位电位（MUP）、面积振幅比（AAR）和旋转次数均发生了变化（P < 0.05）。与对照组相比，更严重受累的肌肉（VL和BB）的平均MUP持续时间也缩短（P < 0.01）。结论：DQEMG能够指示MD累及的严重程度，因为MUP形态学的变化反映了疾病的进行性。肌肉神经，2012
Introduction: Electromyography is useful in the diagnosis of myopathies, but its utility in determining disease severity requires further investigation. In this study we aimed to determine whether decomposition-based quantitative electromyography (DQEMG) could indicate the severity of involvement in a cohort of patients with muscular dystrophies (MDs). Methods: Fifteen patients with facioscapulohumeral (FSHD), limb-girdle (LGMD), and Becker (BMD) muscular dystrophy, and 7 healthy controls, participated in this investigation. Knee extensor isometric strength differentiated the more severe and less severe MD groups. The vastus lateralis (VL), biceps brachii (BB), and tibialis anterior (TA) muscle groups were investigated using DQEMG. Results: All muscles from the MD group showed changes in mean MUP (motor unit potential) AAR (area-to-amplitude ratio), and turns, compared with controls (P < 0.05). More severely affected muscles (VL and BB) also had shortened mean MUP durations compared with controls (P < 0.01). Conclusions: DQEMG was capable of indicating the severity of MD involvement, as changes in MUP morphology reflected the progressive nature of the disease. Muscle Nerve, 2012