Harnessing the immune system in the treatment of cutaneous T cell lymphomas.

Harnessing the immune system in the treatment of cutaneous T cell lymphomas.
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利用免疫系统治疗皮肤T细胞淋巴瘤。

DOI:
10.3389/fonc.2022.1071171
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发表时间:
2022
影响因子:
4.7
通讯作者:
--
中科院分区:
医学3区
文献类型:
--
作者:

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皮肤T细胞淋巴瘤是一种罕见的非霍奇金淋巴瘤的子集,好发于皮肤,具有免疫抑制作用,导致发病率和死亡率。我们现在认识到,抑制免疫系统是疾病进展的重要一步。毫不奇怪,历史上和目前用于治疗这些癌症的疗法具有影响疾病结果的免疫调节功能。通过了解我们疗法的免疫效应,我们可以更好地开发靶向免疫系统的新药物,并改进组合治疗策略,以限制这些癌症的发病率和死亡率。免疫调节作用的治疗药物在使用和开发的皮肤T细胞淋巴瘤将进行审查。
Cutaneous T cell lymphomas are a rare subset of non-Hodgkin’s lymphomas with predilection for the skin with immunosuppressive effects that drive morbidity and mortality. We are now appreciating that suppression of the immune system is an important step in the progression of disease. It should come as no surprise that therapies historically and currently being used to treat these cancers have immune modulating functions that impact disease outcomes. By understanding the immune effects of our therapies, we may better develop new agents that target the immune system and improve combinatorial treatment strategies to limit morbidity and mortality of these cancers. The immune modulating effect of therapeutic drugs in use and under development for cutaneous T cell lymphomas will be reviewed.
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