Neuronal activity related to eye-hand coordination in the primate premotor cortex
Neuronal activity related to eye-hand coordination in the primate premotor cortex
复制标题
灵长类运动前皮层与眼手协调相关的神经元活动
DOI：
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发表时间：
1999
影响因子：
2
通讯作者：
D. Boussaoud
中科院分区：
文献类型：
--
作者：
C. Jouffrais;D. Boussaoud
摘要：为了测试我们之前在背侧前运动皮层（PMd）中报告的凝视信号的功能含义，我们训练两只恒河猴指向触摸屏上呈现的视觉目标，同时控制它们的凝视方向。每只猴子必须执行四项不同的任务。要开始试验，猴子必须将手放在触摸屏中心的起始位置并固定一个固定点。在一项任务中，动物必须对随机出现在圆上八个可能位置之一的外围目标进行伸手运动，同时保持对该虚拟圆的中心的固定（中心固定+伸手）。在第二项任务中，猴子保持对即将到来的外围目标位置的注视，然后到达该位置。延迟一段时间后，目标被打开，猴子做出伸臂动作（目标固定+伸手）。在第三个任务中，猴子在没有任何手臂运动的情况下向目标进行了扫视（扫视）。最后，在第四个任务中，猴子首先对目标进行扫视，然后在延迟后到达目标（扫视+到达）。这种设计使我们能够检查动眼神经环境对 PMd 中手臂相关神经元活动的贡献。我们分析了任务类型对神经元活动的影响，发现许多细胞在信号（26/60；43%）、设定（16/49；33%）和/或运动（15/54；28%）时期表现出任务效果，具体取决于动眼神经历史。这些发现与之前发表的数据一起表明，PMd 以依赖凝视的方式编码肢体运动方向，因此可能在视觉引导伸手过程中眼手协调的大脑机制中发挥重要作用。
Abstract To test the functional implications of gaze signals that we previously reported in the dorsal premotor cortex (PMd), we trained two rhesus monkeys to point to visual targets presented on a touch screen while controlling their gaze orientation. Each monkey had to perform four different tasks. To initiate a trial, the monkey had to put his hand on a starting position at the center of the touch screen and fixate a fixation point. In one task, the animal had to make a reaching movement to a peripheral target randomly presented at one of eight possible locations on a circle while maintaining fixation at the center of this virtual circle (central fixation + reaching). In the second task, the monkey maintained fixation at the location of the upcoming peripheral target and, later, reached to that location. After a delay, the target was turned on and the monkey made a reaching arm movement (target fixation + reaching). In the third task, the monkey made a saccade to the target without any arm movement (saccade). Finally, in the fourth task, the monkey first made a saccade to the target, then reached to it after a delay (saccade + reaching). This design allowed us to examine the contribution of the oculomotor context to arm-related neuronal activity in PMd. We analyzed the effects of the task type on neuronal activity and found that many cells showed a task effect during the signal (26/60; 43%), set (16/49; 33%) and/or movement (15/54; 28%) epochs, depending on the oculomotor history. These findings, together with previously published data, suggest that PMd codes limb-movement direction in a gaze-dependent manner and may, thus, play an important role in the brain mechanisms of eye-hand coordination during visually guided reaching.