Maintenance versus manipulation of information held in working memory: An event-related fMRI study
Maintenance versus manipulation of information held in working memory: An event-related fMRI study
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DOI：
10.1006/brcg.1999.1096
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发表时间：
1999-10-01
影响因子：
2.5
通讯作者：
Lease, J
中科院分区：
文献类型：
--
作者：
D'Esposito, M;Postle, BR;Lease, J
灵长类动物外侧前额叶皮层（PFC）功能组织的一个模型假定，该区域是以背侧/腹侧的方式组织的，分别服务于空间和对象工作记忆。或者，有人提出，侧PFC的背腹细分反映了对工作记忆中的信息进行处理的类型。我们使用事件相关的功能磁共振成像方法来验证这一假设，该方法可以区分在单一试验的时间上分离的行为子组件期间发生的功能变化。受试者在两种类型的试验中执行延迟反应任务，要求他们：（1）在延迟期内保留字母序列（维持）或（2）在延迟期内将序列重新排序为字母顺序（操纵）。在每名受试者中，在这两种类型的试验中，发现背外侧和腹外侧PFC在延迟期间的活动。然而，背外侧PFC活动更大的操纵试验。这些发现与PFC.（C）1999 Academic Press的工作记忆功能组织加工模型相一致。
One model of the functional organization of lateral prefrontal cortex (PFC) in primates posits that this region is organized in a dorsal/ventral fashion subserving spatial and object working memory, respectively. Alternatively, it has been proposed that a dorsal/ventral subdivision of lateral PFC instead reflects the type of processing performed upon information held in working memory. We tested this hypothesis using an event-related fMRI method that can discriminate among functional changes occurring during temporally separated behavioral subcomponents of a single trial. Subjects performed a delayed-response task with two types of trials in which they were required to: (1) retain a sequence of letters across the delay period (maintenance) or (2) reorder the sequence into alphabetical order across the delay period (manipulation). In each subject, activity during the delay period was found in both dorsolateral and ventrolateral PFC in both types of trials. However, dorsolateral PFC activity was greater in manipulation trials. These findings are consistent with the processing model of the functional organization of working memory in PFC. (C) 1999 Academic Press.