Efficient and general method for the synthesis of benzopyrans by ethylenediamine diacetate-catalyzed reactions of resorcinols with α,β-unsaturated aldehydes.: One step synthesis of biologically active (±)-confluentin and (±)-daurichromenic acid
Efficient and general method for the synthesis of benzopyrans by ethylenediamine diacetate-catalyzed reactions of resorcinols with α,β-unsaturated aldehydes.: One step synthesis of biologically active (±)-confluentin and (±)-daurichromenic acid
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DOI：
10.1016/j.tetlet.2005.08.159
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发表时间：
2005-10-31
影响因子：
1.8
通讯作者：
Yoon, SH
中科院分区：
文献类型：
--
作者：
Lee, YR;Choi, JH;Yoon, SH
通过乙二胺二乙酸盐催化的间苯二酚与α，β-不饱和醛的反应，以适度的产率实现了苯并吡喃的有效和通用的合成。作为该方法的应用，在一个步骤中合成了生物学上有趣的confluentin，其已知对组胺释放具有抑制作用。此外，一步成功合成了具有高效抗HIV活性的天然蝙蝠葛色烯酸。(c)2005年由Elsevier Ltd.出版
An efficient and general synthesis of benzopyrans is achieved by ethylenediamine diacetate-catalyzed reactions of resorcinols with alpha,beta-unsaturated aldehydes in moderated yields. As an application of this methodology, biologically interesting confluentin, which was known to have an inhibitory effect on histamine release is synthesized in one step. Also, natural daurichromenic acid, which has highly potent anti-HIV activity, is successfully synthesized in one step. (c) 2005 Published by Elsevier Ltd.