Cardiovascular nuclear imaging: From perfusion to molecular function
Cardiovascular nuclear imaging: From perfusion to molecular function
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DOI：
10.1136/hrt.2007.122747
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发表时间：
2008-06-01
期刊：
影响因子：
5.7
通讯作者：
Bengel, Frank M.
中科院分区：
文献类型：
--
作者：
Higuchi, Takahiro;Bengel, Frank M.
虽然核心脏病学已经通过心肌灌注成像深入临床心血管医学，但近年来的新进展表明该领域正在发生变化。鉴于现有成像技术的精度不断提高，多种新型分子机制示踪剂的引入，以及通过小动物成像提高的翻译能力，可以预见，核成像将越来越多地超越灌注和功能的评估，以针对个体疾病过程中涉及的特定生物机制。由于分子核心脏病学具有检测人体和实验动物体内非常低浓度分子的独特能力，这些新的分子核心脏病学方法有望在个性化医疗的发展和新的特异性治疗的引入中发挥关键作用。
While nuclear cardiology is well rooted in clinical cardiovascular medicine through myocardial perfusion imaging, new developments in recent years indicate a change in the field. Given the increasing precision of available imaging technology, the introduction of multiple new tracers specific for molecular mechanisms, and the improving translational capabilities through small animal imaging, it is envisioned that nuclear imaging will increasingly go beyond the assessment of perfusion and function, in order to target specific biomechanisms involved in individual disease processes. Due to the unique ability to detect molecules in very low concentrations throughout the body of humans as well as experimental animals, these new approaches of molecular nuclear cardiology are expected to play a key role in the evolution of personalised medicine and in the introduction of novel specific therapies.