A method of testing analgesics in man.
A method of testing analgesics in man.
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一种测试人体镇痛药的方法。
DOI：
10.1016/s0140-6736(48)91115-5
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发表时间：
1948
期刊：
影响因子：
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通讯作者：
C. Keele
中科院分区：
文献类型：
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作者：
A. Hewer;C. Keele
因此，很明显，也不奇怪，微生物可以很容易地通过浸泡在血浆和肉汤中的敷料生长，并且似乎可以安全地假设，如果营养液是烧伤表面的正常渗出物，同样会发生同样的情况，因为这些相同的微生物的小接种物-绿脓杆菌-已经发现在这种渗出物（水泡液）中自由生长。我们不知道通过在体内用浆液性渗出物或血液浸泡的敷料实际上发生这种生物体向内生长的频率。这将永远很难证明。它可能发生在AB的情况下，它很可能是造成其他一些附加感染的原因。绿脓杆菌，在1947年下半年，在新鲜烧伤的第一次和第二次敷料之间（最大渗出期）发展（Colebrook等，1948）。它也可能是许多早期感染的原因，
DISCUSSIONIt is therefore clear, nor is it surprising, that organisms can readily grow through a dressing steeped in plasma plus broth, and it seems a safe assumption that the same will happen if the nutrient fluid is the normal exudate from a burned surface, since small inocula of these same organisms— hæ molytic streptococcus, staphylococcus, Pioteus, and Ps. pyocyanea— have been found to grow freely in such exudate (blister fluid). How often such an ingrowth of organisms does in fact occur through dressings soaked-in vivo with serous exudate or blood we do not know. It will always be difficult to prove. It probably happened in the case’of AB, and it may well have been responsible for a number of other added infections by Ps. pyocyanea which developed between the first and second dressings of fresh burns (the period of maximal exudation) during the latter part of 1947 (Colebrook et al. 1948). It may also have been responsible for many of the early infections of