Brain structural and cognitive correlates of clock drawing performance in Alzheimer's disease
Brain structural and cognitive correlates of clock drawing performance in Alzheimer's disease
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DOI：
10.1017/s1355617799566034
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发表时间：
1999-09-01
影响因子：
2.6
通讯作者：
Pfefferbaum, A
中科院分区：
文献类型：
--
作者：
Cahn-Weiner, DA;Sullivan, EV;Pfefferbaum, A
时钟绘制测试（CDT）被广泛用于痴呆症的评估，并且已知对检测阿尔茨海默病（AD）等神经退行性疾病的缺陷很敏感。CDT的表现不仅取决于视觉空间和建构能力，还取决于概念和执行功能；因此，它很可能是由多个脑区介导的。本研究的目的是确定AD中CDT表现的组成认知过程和区域皮质体积。在29例疑似AD患者中，CDT表现与右半球区域灰质体积显著相关，而与左半球区域灰质体积无关。具体而言，CDT评分与右侧前、后颞上叶体积显著相关。CDT得分与语义知识、执行功能、视觉构建和接受性语言的测试有显著的关系。这些。结果表明，在AD患者中，CDT表现可归因于多个认知领域的损伤，但具体与右侧颞叶皮层的区域体积损失有关。
The Clock Drawing Test (CDT) is widely used in the assessment of dementia and is known to be sensitive to the detection of deficits in neurodegenerative disorders such as Alzheimer's disease (AD). CDT performance is dependent not only on visuospatial and constructional abilities, but also on conceptual and executive functioning; therefore, it is likely to be mediated by multiple brain regions. The purpose of the present study was to identify component cognitive processes and regional cortical volumes that contribute to CDT performance in AD. in 29 patients with probable AD, CDT performance was significantly related to right-, but not left-hemisphere, regional gray matter volume. Specifically, CDT score correlated significantly with the right anterior and posterior superior temporal lobe volumes. CDT scores showed significant relationships with tests of semantic knowledge, executive function, and visuoconstruction, and receptive language. These. results suggest that in AD patients, CDT performance is attributable to impairment in multiple cognitive domains but is related specifically to regional volume loss of right temporal cortex.