An Update on Optical Coherence Tomography Angiography in Diabetic Retinopathy.
An Update on Optical Coherence Tomography Angiography in Diabetic Retinopathy.
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DOI：
10.4103/jovr.jovr_57_18
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发表时间：
2018-10
影响因子：
2
通讯作者：
Falavarjani KG
中科院分区：
文献类型：
--
作者：
Khadamy J;Abri Aghdam K;Falavarjani KG
光学相干断层扫描血管造影 (OCTA) 是一种新颖的非侵入性成像方式，用于视网膜和视神经毛细血管网络的 3 维可视化。在本文中，使用搜索词“糖尿病视网膜病变”、“糖尿病性黄斑水肿”、“糖尿病”和“光学相干断层扫描血管造影”对 PubMed 数据库中的相关原始文章进行了全面综述。人们发现 OCTA 可以检测糖尿病早期的微血管变化，甚至在它们变得临床明显之前。血管变化的形态学和定性评估有助于确定糖尿病视网膜病变 (DR) 的病理生理过程、活动、治疗和随访。血管密度和中心凹无血管区是研究最多的量化指标，被证明是 DR 的早期预测因素，与 DR 严重程度和视觉功能相关，并且可用于预测治疗反应。 OCTA 已被证明是 DR 治疗中荧光素血管造影的一种有前景的替代方案。需要进一步的研究来确定 OCTA 在 DR 常规临床管理中的作用。
Optical coherence tomography angiography (OCTA) is a novel non-invasive imaging modality for 3-dimensional visualization of retinal and optic nerve capillary networks. In this article, a comprehensive review of relevant original articles in the PubMed database was performed using the search terms “diabetic retinopathy,” “diabetic macular edema,” “diabetes mellitus,” and “optical coherence tomography angiography.” OCTA was found to detect microvascular changes early in diabetes mellitus, even before they become clinically evident. Morphological and qualitative assessment of vascular changes can help to determine the pathophysiological processes, activity, treatment, and follow-up of diabetic retinopathy (DR). Vessel density and foveal avascular zone are the most investigated quantified indices shown to be early predictors of DR, correlated to DR severity and visual function, and useful in predicting response to treatment. OCTA has shown to be a promising alternative to fluorescein angiography in the management of DR. Further studies are warranted to determine the role of OCTA in the routine clinical management of DR.