The Mechanism of the Calorigenic Action of Thyroid Hormone
The Mechanism of the Calorigenic Action of Thyroid Hormone
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甲状腺激素的生热作用机制
DOI：
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发表时间：
1971
期刊：
影响因子：
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通讯作者：
I. Edelman
中科院分区：
文献类型：
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作者：
F. Ismail;I. Edelman
在早期的研究中，我们提出甲状腺激素刺激Na+泵的能量利用介导了产热反应。本研究测定了三碘甲状腺原氨酸（T3）对肝脏、肾脏和大脑总耗氧量（qoo2）、瓦阿巴因敏感耗氧量（qoo2 (t)）和nak - atp酶的影响。在肝脏中，在去甲状腺或甲状腺功能正常的大鼠中，T3产生的qoo2增加的约90%可归因于qoo2 (t)的增加。在肾脏中，qoo2 (t)的增加占去甲状腺大鼠Q OO2增加的29%，占甲状腺功能正常大鼠Q OO2增加的46%。T3对正常甲状腺大鼠脑切片qoo2和qoo2 (t)无明显影响。T3对匀浆中nak - atp酶活性的影响如下：甲状腺功能正常大鼠肝脏+81%，甲状腺功能低下大鼠肝脏+54%。肾脏：甲状腺功能正常大鼠+21%，甲状腺功能低下大鼠+69%。T3对正常甲状腺大鼠脑匀浆nak - atp酶和mg - atp酶活性无显著影响。肝质膜NaK-ATPase升高69%，Mg-ATPase和5′-核苷酸酶活性无明显变化。这些结果表明，甲状腺激素对nak - atp酶活性的刺激是不同的。这种效应至少可以部分解释这些激素的产热作用。
In an earlier study, we proposed that thyroid hormone stimulation of energy utilization by the Na+ pump mediates the calorigenic response. In this study, the effects of triiodothyronine (T3) on total oxygen consumption (Q OO2), the ouabain-sensitive oxygen consumption [Q OO2(t)], and NaK-ATPase in liver, kidney, and cerebrum were measured. In liver, ∼90% of the increase in Q OO2 produced by T3 in either thyroidectomized or euthyroid rats was attributable to the increase in Q OO2(t). In kidney, the increase in Q OO2(t) accounted for 29% of the increase in Q OO2 in thyroidectomized and 46% of the increase in Q OO2 in euthyroid rats. There was no demonstrable effect of T3 in euthyroid rats on Q OO2 or Q OO2(t) of cerebral slices. The effects of T3 on NaK-ATPase activity in homogenates were as follows: In liver +81% from euthyroid rats and +54% from hypothyroid rats. In kidney, +21% from euthyroid rats and +69% from hypothyroid rats. T3 in euthyroid rats produced no significant changes in NaK-ATPase or Mg-ATPase activity of cerebral homogenates. Liver plasma membrane fractions showed a 69% increase in NaK-ATPase and no significant changes in either Mg-ATPase or 5'-nucleotidase activities after T3 injection. These results indicate that thyroid hormones stimulate NaK-ATPase activity differentially. This effect may account, at least in part, for the calorigenic effects of these hormones.