The neuroanatomies of schizophrenia.
The neuroanatomies of schizophrenia.
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精神分裂症的神经解剖学。
DOI：
10.1093/schbul/23.3.367
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发表时间：
1997
影响因子：
6.6
通讯作者：
CarpenterJr,WT
中科院分区：
文献类型：
--
作者：
Buchanan,RW;CarpenterJr,WT
精神分裂症是一种脑部疾病，尽管进行了深入的研究，但其病理生理仍未被发现。未能描述精神分裂症的神经解剖学部分与神经病理异常的微妙性质和未能充分解决精神分裂症的病理生理异质性有关。精神分裂症的症状聚集在相对独立的症状复合体中，这表明每个复合体可能有不同的神经基础。如果这是真的，那么精神分裂症的神经解剖学更好地被描述为症状复合体的单独神经解剖学。然而，使用症状复合体来指导未来的神经解剖学研究提出了关键的方法学问题，包括区分主要和次要症状，特征和状态特征，以及连续变量和分类变量。决定性假设检验要求在研究设计中解决这些问题。
Schizophrenia is a brain disease whose pathophysiology has escaped detection despite intensive investigation. The failure to delineate the neuroanatomy of schizophrenia is related in part to both the subtle nature of the neuropathological abnormalities and to the failure to address adequately the pathophysiological heterogeneity of schizophrenia. The symptoms of schizophrenia aggregate into relatively independent symptom complexes, which suggests that there may be a distinct neural substrate for each complex. If this is true, then the neuroanatomy of schizophrenia is better addressed as the separate neuroanatomies of symptom complexes. However, the use of symptom complexes to guide future neuroanatomical investigations raises crucial methodological issues, including the differentiation of primary versus secondary symptoms, trait versus state characteristics, and continuous versus categorical variables. Decisive hypothesis testing requires that these issues be addressed in study design.