Metabolic regulation and gene expression during aestivation.
Metabolic regulation and gene expression during aestivation.
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DOI：
10.1007/978-3-642-02421-4_2
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发表时间：
2010
影响因子：
--
通讯作者：
K. Storey;J. Storey
中科院分区：
文献类型：
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作者：
K. Storey;J. Storey
夏眠的生化调节是一种有氧代谢低下的状态，其作用包括强烈的整体抑制代谢率，通过不同的细胞功能重新优先考虑能量使用，以及增强防御，如蛋白质伴侣和抗氧化剂，有助于长期延长寿命。这是通过包括细胞内信号级联的差异作用、可逆蛋白磷酸化以改变多种酶和功能蛋白的活性状态、转录和翻译的全局抑制以及选择性基因上调的机制来实现的。最近的进展，了解夏眠的调节进行了讨论，特别强调陆地蜗牛和无尾类模型。
The biochemical regulation of aestivation, a state of aerobic hypometabolism, achieves actions including strong overall suppression of metabolic rate, reprioritization of energy use by diverse cell functions, and enhancement of defenses such as protein chaperones and antioxidants that aid long-term life extension. This is accomplished by mechanisms that include differential action of intracellular signaling cascades, reversible protein phosphorylation to alter the activity states of multiple enzymes and functional proteins, global suppression of transcription and translation, and selective gene upregulation. Recent advances in understanding the regulation of aestivation are discussed with a particular emphasis on land snail and anuran models.