Role of brain thromboxane A2 in the release of noradrenaline and adrenaline from adrenal medulla in rats.
Role of brain thromboxane A2 in the release of noradrenaline and adrenaline from adrenal medulla in rats.
复制标题
脑血栓素 A2 在大鼠肾上腺髓质释放去甲肾上腺素和肾上腺素中的作用。
DOI：
10.1016/s0014-2999(03)01629-7
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发表时间：
2003
影响因子：
5
通讯作者：
K. Yokotani
中科院分区：
文献类型：
--
作者：
S. Okada;Y. Murakami;K. Yokotani
血浆去甲肾上腺素反映肾上腺髓质和交感神经的释放；然而，肾上腺去甲肾上腺素释放的确切机制仍有待阐明。本研究旨在确定乌拉坦麻醉大鼠中枢注射加压素和促肾上腺皮质激素释放激素 (CRH) 诱导的血浆去甲肾上腺素的来源。脑室内给予加压素（0.2 nmol/动物）和CRH（1.5 nmol/动物）升高去甲肾上腺素和肾上腺素的血浆水平。脑室内给予吲哚美辛[1.2 μmol (500 μg)/动物]（环氧合酶抑制剂）消除了加压素和 CRH 诱导的去甲肾上腺素和肾上腺素升高。脑室内注射呋格雷酯 [1.8 μmol (500 μg)/动物]（血栓素 A2 合酶抑制剂）可消除加压素诱导的去甲肾上腺素和肾上腺素升高，而该试剂仅减弱 CRH 引起的血浆肾上腺素升高。急性双侧肾上腺切除术消除了加压素引起的去甲肾上腺素和肾上腺素的升高，而该手术仅降低了 CRH 引起的肾上腺素的升高。这些结果表明，肾上腺髓质和交感神经释放去甲肾上腺素是由不同的中枢机制介导的。加压素诱导的肾上腺髓质去甲肾上腺素释放是由脑血栓素 A2 介导的机制介导的，而 CRH 诱导的交感神经去甲肾上腺素释放是由脑前列腺素类（血栓素 A2 除外）介导的机制介导的。在大鼠中，加压素和 CRH 诱导的肾上腺髓质释放肾上腺素也是由脑血栓素 A2 介导的机制介导的。
Plasma noradrenaline reflects the release from adrenal medulla and sympathetic nerves; however, the exact mechanisms of adrenal noradrenaline release remain to be elucidated. The present study was designed to characterize the source of plasma noradrenaline induced by centrally administered vasopressin and corticotropin-releasing hormone (CRH) in urethane-anesthetized rats. Intracerebroventricularly administered vasopressin (0.2 nmol/animal) and CRH (1.5 nmol/animal) elevated plasma levels of noradrenaline and adrenaline. Intracerebroventricularly administered indomethacin [1.2 μmol (500 μg)/animal] (an inhibitor of cyclooxygenase) abolished the elevations of both noradrenaline and adrenaline induced by vasopressin and CRH. Intracerebroventricularly administered furegrelate [1.8 μmol (500 μg)/animal] (an inhibitor of thromboxane A2synthase) abolished the elevations of both noradrenaline and adrenaline induced by vasopressin, while the reagent only attenuated the elevation of plasma adrenaline evoked by CRH. Acute bilateral adrenalectomy abolished the elevation of both noradrenaline and adrenaline induced by vasopressin, while the procedure reduced only the elevation of adrenaline induced by CRH. These results suggest that the release of noradrenaline from adrenal medulla and sympathetic nerves is mediated by different central mechanisms. The vasopressin-induced noradrenaline release from adrenal medulla is mediated by brain thromboxane A2-mediated mechanisms, while the CRH-induced noradrenaline release from sympathetic nerves is mediated by brain prostanoid (other than thromboxane A2)-mediated mechanisms. The vasopressin- and CRH-induced adrenaline release from adrenal medulla is also mediated by brain thromboxane A2-mediated mechanisms in rats.
血管紧张素 II 促进髓大鼠肾上腺场刺激的升压反应。
DOI：
10.1152/ajpregu.1988.254.1.r95
发表时间：
1988
期刊：
The American journal of physiology
影响因子：
--
作者：
Vollmer,RR;Corey,SP;Fluharty,SJ
通讯作者：
Fluharty,SJ
肾上腺髓质中肾上腺素和去甲肾上腺素细胞的选择性神经调节——心血管影响。
DOI：
10.3109/10641969609081778
发表时间：
1996
期刊：
Clinical and experimental hypertension (New York, N.Y. : 1993)
影响因子：
--
作者：
Vollmer,RR
通讯作者：
Vollmer,RR