Metastases of thin melanomas
Metastases of thin melanomas
复制标题
薄黑色素瘤的转移
作者：
H. Trau;D. Rigel;M. Harris;A. Kopf;R. Friedman;S. Gumport;R. Bart;W. Robson N. Grier
尽管皮肤的薄恶性黑色素瘤，即厚度小于0.76毫米的黑色素瘤通常不会转移，但最近有报道称，当存在组织学消退时，此类病变可能具有更大的扩散倾向。然而，这一点在本研究中并不明显，在该研究中，连续 41 个薄病灶中只有一个黑色素瘤发生转移，这些病灶是阶梯切片的，并且有组织学消退的证据。对这种差异的可能解释是其他作者未能仅包括原发性黑色素瘤的阶梯切片标本的材料和/或这种恶性肿瘤的生物学行为的地理差异。
Although thin malignant melanomas, i.e., those less than 0.76 mm in thickness, of the skin generally do not metastasize, it has been recently reported that when histologic regression is present, such lesions may then have a greater propensity for dissemination. However, this was not apparent in this study in which only one melanoma metastasized in a consecutive series of 41 thin lesions which were stepsectioned and had evidence of regression histologically. Possible explanations for this discrepancy are the failure of other authors to include only step‐sectioned specimens of the primary melanomas in their material and/or geographic differences in the biologic behavior of this malignant neoplasm.