NOVEL ASSAY FOR THE INFLUENZA-VIRUS M2 CHANNEL ACTIVITY
NOVEL ASSAY FOR THE INFLUENZA-VIRUS M2 CHANNEL ACTIVITY
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DOI：
10.1016/0014-5793(94)01369-c
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发表时间：
1995-01-09
期刊：
影响因子：
3.5
通讯作者：
FORGEY, RW
中科院分区：
文献类型：
--
作者：
GIFFIN, K;RADER, RK;FORGEY, RW
研究了非洲爪蟾卵母细胞中甲型流感M2离子通道的表达及其活性。基于通道的激活特性，开发了一种高通量，非电生理筛选试验，以确定新的通道抑制剂。这将有助于发现治疗流感病毒感染的新药。
The influenza A M2 ion channel was expressed and activity characterized in Xenopus oocytes. Based on the activation properties of the channels, a high throughput, non-electrophysiological screening assay was developed in order to identify novel inhibitors of the channel. This will facilitate discovery of novel agents to treat influenza viral infections.