Progressive interstitial lung disease from prolonged methotrexate therapy.
Progressive interstitial lung disease from prolonged methotrexate therapy.
复制标题
长期甲氨蝶呤治疗导致进行性间质性肺疾病。
DOI：
10.1001/archderm.1978.01640240042014
复制
发表时间：
1978
影响因子：
--
通讯作者：
D. H. Waite
中科院分区：
文献类型：
--
作者：
R. L. Kaplan;D. H. Waite
进行性间质纤维化与X线蜂窝状发展的情况下，银屑病患者谁一直在甲氨蝶呤方案18年。检查发现肺力学的限制性和阻塞性缺陷以及肺泡毛细血管膜的气体转移严重受损。甲氨蝶呤停药后，动脉血气和肺弥散功能均有所改善。肺间质纤维化是甲氨蝶呤治疗银屑病的潜在并发症。
Progressive interstitial fibrosis with roentgenographic honeycombing developed in the case of a psoriatic patient who had been on a regimen of methotrexate for 18 years. Examination revealed a combined restrictive and obstructive defect in pulmonary mechanics and severe compromise of gas transfer across the pulmonary alveolar-capillary membrane. Improvement in the level of arterial blood gases and pulmonary diffusing capacity occurred after discontinuation of methotrexate therapy. Interstitial fibrosis of the lung is a potential complication of methotrexate therapy for psoriasis.