Alpha 2 adrenergic receptor subtypes in depression: a candidate gene study.
Alpha 2 adrenergic receptor subtypes in depression: a candidate gene study.
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DOI：
10.1016/0165-0327(92)90005-q
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发表时间：
1992-07
影响因子：
6.6
通讯作者：
Z. Wang;R. Crowe;V. Tanna;G. Winokur
中科院分区：
文献类型：
--
作者：
Z. Wang;R. Crowe;V. Tanna;G. Winokur
Alpha2adrenergic receptors play an important role in regulating the neuronal release of norepinephrine through presynaptic feedback inhibition in the locus ceruleus. Therefore, alpha2adrenergic autoreceptors may underlie some aspects of the pathogenesis and symptomatic expression of depressive illness. We studied two brain-expressed alpha2adrenergic receptor genes as genetic markers in linkage analyses in 17 multiplex pedigrees of unipolar depression. Neither of the genes was supportive of linkage to depression. Lod scores of less than -2 were found in both familial pure depressive disease pedigrees and in depression spectrum disease pedigrees. Therefore, we conclude that depression in our pedigrees is not related to mutations in the two alpha2adrenergic receptor genes tested.
