Predictors of adherence in the Women's Health Initiative Calcium and Vitamin D Trial.
Predictors of adherence in the Women's Health Initiative Calcium and Vitamin D Trial.
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DOI：
10.3200/bmed.34.4.145-155
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发表时间：
2009
期刊：
影响因子：
--
通讯作者：
Wu L
中科院分区：
文献类型：
--
作者：
Brunner R;Dunbar-Jacob J;Leboff MS;Granek I;Bowen D;Snetselaar LG;Shumaker SA;Ockene J;Rosal M;Wactawski-Wende J;Cauley J;Cochrane B;Tinker L;Jackson R;Wang CY;Wu L
The authors analyzed data from the Women’s Health Initiative (WHI) Calcium and Vitamin D Supplementation Trial (CaD) to learn more about factors affecting adherence to clinical trial study pills (both active and placebo). Most participants (36,282 postmenopausal women aged 50–79 years) enrolled in CaD 1 year after joining either a hormone trial or the dietary modification trial of WHI. The WHI researchers measured adherence to study pills by weighing the amount of remaining pills at an annual study visit; adherence was primarily defined as taking ≥ 80% of the pills. The authors in this study examined a number of behavioral, demographic, procedural, and treatment variables for association with study pill adherence. They found that relatively simple procedures (ie, phone contact early in the study [4 weeks post randomization] and direct social contact) later in the trial may improve adherence. Also, at baseline, past pill-use experiences, personal supplement use, and relevant symptoms may be predictive of adherence in a supplement trial.
