Blood pressure and coeliac artery blood flow responses during increased inspiratory muscle work in healthy males
Blood pressure and coeliac artery blood flow responses during increased inspiratory muscle work in healthy males
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DOI：
10.1113/ep090504
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发表时间：
2022-07-11
影响因子：
2.7
通讯作者：
Katayama，Keisho
中科院分区：
文献类型：
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作者：
Shiozawa，Kana;Kashima，Hideaki;Katayama，Keisho
新发现本研究的中心问题是什么？呼吸功的增加和代谢物的积累通过呼吸肌诱导的代谢反射对神经和心血管产生影响。呼吸肌诱导的代谢反射对人体内脏血流量的影响尚不清楚。主要发现及其重要性是什么？腹腔动脉血流量在吸气阻力呼吸过程中逐渐减少，伴随着动脉血压的进行性升高。这是可能的，呼吸肌诱导的代谢反射有助于内脏血流量regulation.AbstractThe目的本研究是澄清增加吸气肌工作对腹腔动脉血流的影响。11名健康的年轻男性完成了这项研究。受试者在存在或不存在吸气阻力的情况下进行自主过度通气（负荷或非负荷试验;潮气量为肺活量的40%，呼吸频率为20次/min）。负荷试验在吸气阻力（最大吸气压力的40%）下进行，当受试者无法再维持目标潮气量或呼吸频率时终止。非负荷试验在没有吸气阻力的情况下进行，并且持续时间与负荷试验相同。用手指光电容积描记法记录动脉血压，用多普勒超声测量腹腔动脉血流量。在负荷试验期间，平均动脉血压逐渐升高（平均值± SD;从89.0 ± 10.8 mmHg升高至103.9 ± 17.3 mmHg），但在非负荷试验中未升高（从88.7 ± 5.9 mmHg升高至90.4 ± 9.9 mmHg）。腹腔动脉血流量和腹腔血管传导性在负荷试验过程中逐渐下降（从601.2 ± 155.7到482.6 ± 149.5 mL/min和从6.9 ± 2.2到4.8 ± 1.7 mL/min/mmHg，但在非负荷试验中保持不变（分别从630.7 ± 157.1至635.6 ± 195.7 mL/min和从7.1 ± 1.8至7.2 ± 2.9 mL/min/mmHg）。这些结果表明，增加吸气肌功影响内脏血流量调节，我们认为这可能是由吸气肌诱导的代谢反射介导的。
New FindingsWhat is the central question of this study?Increased work of breathing and the accumulation of metabolites have neural and cardiovascular consequences through a respiratory muscle‐induced metaboreflex. The influence of the respiratory muscle‐induced metaboreflex on splanchnic blood flow in humans remains unknown.What is the main finding and its importance?Coeliac artery blood flow decreased gradually during inspiratory resistive breathing, accompanied by a progressive increase in arterial blood pressure. It is possible that the respiratory muscle‐induced metaboreflex contributes to splanchnic blood flow regulation.AbstractThe purpose of this study was to clarify the effect of increasing inspiratory muscle work on coeliac artery blood flow. Eleven healthy young males completed the study. The subjects performed voluntary hyperventilation with or without inspiratory resistance (loading or non‐loading trial; tidal volume of 40% of vital capacity and breathing frequency of 20 breaths/min). The loading trial was conducted with inspiratory resistance (40% of maximal inspiratory pressure) and was terminated when the subjects could no longer maintain the target tidal volume or breathing frequency. The non‐loading trial was conducted without inspiratory resistance and was of the same duration as the loading trial. Arterial blood pressure was recorded using finger photoplethysmography, and coeliac artery blood flow was measured using Doppler ultrasound. Mean arterial blood pressure increased gradually during the loading trial (mean ± SD; from 89.0 ± 10.8 to 103.9 ± 17.3 mmHg) but not in the non‐loading trial (from 88.7 ± 5.9 to 90.4 ± 9.9 mmHg). Coeliac artery blood flow and coeliac vascular conductance decreased gradually during the loading trial (from 601.2 ± 155.7 to 482.6 ± 149.5 mL/min and from 6.9 ± 2.2 to 4.8 ± 1.7 mL/min/mmHg, respectively) but were unchanged in the non‐loading trial (from 630.7 ± 157.1 to 635.6 ± 195.7 mL/min and from 7.1 ± 1.8 to 7.2 ± 2.9 mL/min/mmHg, respectively). These results show that increasing inspiratory muscle work affects splanchnic blood flow regulation, and we suggest that this might be mediated by the inspiratory muscle‐induced metaboreflex.