The effects of dexamethasone administration and withdrawal on water permeability across the blood‐brain barrier
The effects of dexamethasone administration and withdrawal on water permeability across the blood‐brain barrier
复制标题
地塞米松给药和停药对血脑屏障水渗透性的影响
DOI：
10.1002/ana.410130107
复制
发表时间：
1983
影响因子：
11.2
通讯作者：
J. Mcculloch
中科院分区：
文献类型：
--
作者：
Alison C. Reid;Alison C. Reid;Alison C. Reid;G. Teasdale;J. Mcculloch
我们研究了地塞米松给药和停药对清醒大鼠中枢神经系统局部脑血流量（CBF）和水渗透表面积（PS）积的影响。CBF无明显变化。地塞米松治疗产生了显着减少PS产品的水在大脑皮层，而地塞米松的撤出导致显着增加。在停用地塞米松的大鼠中，大脑皮层的含水量也增加。这些发现可能有助于理解某些患者脑肿胀的发病机制。
We examined the effects of dexamethasone administration and withdrawal on regional cerebral blood flow (CBF) and the permeability surface area (PS) product for water in the central nervous system of conscious rats. There were no significant changes in CBF. Dexamethasone treatment produced a significant decrease in the PS product for water in the cerebral cortex, while withdrawal of dexamethasone resulted in a significant increase. Water content of the cerebral cortex was also increased in rats from which dexamethasone had been withdrawn. These findings may help in understanding the pathogenesis of brain swelling in some patients.