Proprioceptive and cutaneous representations in the rat ventral posterolateral thalamus
Proprioceptive and cutaneous representations in the rat ventral posterolateral thalamus
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DOI：
10.1152/jn.01206.2007
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发表时间：
2008-05-01
影响因子：
2.5
通讯作者：
Chapin, John K.
中科院分区：
文献类型：
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作者：
Francis, Joseph T.;Xu, Shaohua;Chapin, John K.
确定本体感受信息在大鼠腹后外侧（VPL）中的表达方式和位置对于我们进一步研究这种感觉在运动控制和学习过程中是如何被利用的非常重要。在这里，我们证明了使用电生理技术，大鼠腹外侧核（rVPL，-2至-2.5毫米前囟）的吻侧部分进行了大量的本体感受信息。该区域的尾部是皮肤感受野为焦点的区域（中间VPL的mVPL，-2.5至-3.2 mm前囟），具有前肢和后肢的精细地形图。前爪用内侧的第1个趾表示，随后的每个趾逐渐向外侧，所有这些趾都在脚垫的背侧。尾侧VPL（cVPL，-3.2至-4.0 mm前囟）具有宽的感受野，并且是第1层和第2层以及背柱核的靶，并且可以代表通过VPL的伤害性信息流。因此，我们建议，VPL可以被认为是三个亚核-吻，中，尾VPL每一个优先携带不同形式的信息。这种通过大鼠VPL的信息流模式与许多灵长类动物相似，尽管明显旋转，表明大鼠中的这些区域（rVPL，mVPL和cVPL）在灵长类动物中已进一步分化，它们被视为独立的核（VPS，VPL和VPI/VMpo）。
Determining how and where proprioceptive information is represented in the rat ventral posterolateral (VPL) is important in allowing us to further investigate how this sense is utilized during motor control and learning. Here we demonstrate using electrophysiological techniques that the rostral portion of the rat VPL nucleus (rVPL, -2 to -2.5 mm bregma) carries a large amount of proprioceptive information. Caudal to this region is a zone where the cutaneous receptive fields are focal (mVPL for middle VPL, -2.5 to -3.2 mm bregma) with a fine topographic map of the fore- and hindlimbs. The forepaw is represented with digit 1 medial and each subsequent digit increasingly lateral, all of which are dorsal to the pads. The caudal VPL (cVPL, -3.2 to -4.0 mm bregma) has broad receptive fields and is the target of lamina 1 and lamina 2, as well as the dorsal column nuclei, and may represent the flow of nociceptive information through the VPL. Thus we propose that the VPL may be thought of as three subnuclei-the rostral, middle, and caudal VPL each carrying preferentially a different modality of information. This pattern of information flow through the rat VPL is similar, although apparently rotated, to that of many primates, indicating that these regions in the rat ( rVPL, mVPL, and cVPL) have become further differentiated in primates where they are seen as separate nuclei (VPS, VPL, and VPI/VMpo).