NIR absorbing DICPO derivatives applied to wide range of pH and detection of glutathione in tumor
NIR absorbing DICPO derivatives applied to wide range of pH and detection of glutathione in tumor
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近红外吸收 DICPO 衍生物适用于广泛的 pH 范围和肿瘤中谷胱甘肽的检测
DOI：
10.1016/j.tet.2015.08.020
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发表时间：
2015-10-14
期刊：
影响因子：
2.1
通讯作者：
Lu, Wei
中科院分区：
文献类型：
--
作者：
Bao, Bin;Liu, Meng;Lu, Wei
开发了新的DPCO衍生物，可在广泛的pH值范围内应用。在pH值为5.0~9.0的溶液中，CI-DPCO表现出比DPCO更好的光学性质，更适合于探针的设计，特别是对于酸性的肿瘤微环境的成像。以CI-DPCO为探针，设计了1个用于检测GSH的探针。在pH为5.7和7.4的环境中，探针I对GSH反应灵敏，并检测到较强的近红外荧光。此外，探针1对活细胞中的内源性GSH有良好的响应，表明CI-DPCO具有设计其他肿瘤相关探针的潜力。(C)2015爱思唯尔有限公司所有权利
New DPCO derivatives were developed for application at a wide range of pH values. CI-DPCO exhibited better optical properties than DPCO in solutions with pH values from 5.0 to 9.0 and was preferable for the design of probes, especially for the imaging of a tumor micro-environment which is acidic. With CI-DPCO probe 1 was designed for the detection of GSH. Probe I was sensitive to GSH in environments at pH values of 5.7 and 7.4, and strong near-infrared fluorescence was detected. Moreover, probe 1 had good response to the endogenous GSH in living cells, which suggested that CI-DPCO has potential in the design of other tumor-associated probes. (c) 2015 Elsevier Ltd. All rights