Pregnancy Vaccination with Gold Glyco-Nanoparticles Carrying Listeria monocytogenes Peptides Protects against Listeriosis and Brain- and Cutaneous-Associated Morbidities.
Pregnancy Vaccination with Gold Glyco-Nanoparticles Carrying Listeria monocytogenes Peptides Protects against Listeriosis and Brain- and Cutaneous-Associated Morbidities.
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DOI：
10.3390/nano6080151
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发表时间：
2016-08-19
期刊：
影响因子：
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通讯作者：
Álvarez-Domínguez C
中科院分区：
文献类型：
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作者：
Calderón-Gonzalez R;Terán-Navarro H;Frande-Cabanes E;Ferrández-Fernández E;Freire J;Penadés S;Marradi M;García I;Gomez-Román J;Yañez-Díaz S;Álvarez-Domínguez C
李斯特菌病是胎儿和新生儿的致命感染，在新生儿期有两种主要临床发病率，脑膜炎和弥漫性皮肤病变。在这项研究中，我们用两种载有两种肽的金糖纳米颗粒（GNP）接种妊娠雌性，这两种肽是溶血素肽91-99（LL 0 91 -99）或甘油醛-3-磷酸脱氢酶1-22肽（GAPDH 1 -22）。接种疫苗的母亲所生的新生儿没有细菌并且健康，而未接种疫苗的小鼠表现出明显的大脑病变和皮肤黑素细胞减少。因此，这些纳米颗粒疫苗是有效的措施，为处于胎盘炎高风险的孕妇提供穿过胎盘的有趣疗法。
Listeriosis is a fatal infection for fetuses and newborns with two clinical main morbidities in the neonatal period, meningitis and diffused cutaneous lesions. In this study, we vaccinated pregnant females with two gold glyconanoparticles (GNP) loaded with two peptides, listeriolysin peptide 91–99 (LLO91–99) or glyceraldehyde-3-phosphate dehydrogenase 1–22 peptide (GAPDH1–22). Neonates born to vaccinated mothers were free of bacteria and healthy, while non-vaccinated mice presented clear brain affections and cutaneous diminishment of melanocytes. Therefore, these nanoparticle vaccines are effective measures to offer pregnant mothers at high risk of listeriosis interesting therapies that cross the placenta.