Auto‐Anti‐Kpb Associated with Weakened Antigenicity in the Kell Blood Group System: A Second Example
Auto‐Anti‐Kpb Associated with Weakened Antigenicity in the Kell Blood Group System: A Second Example
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自身抗 Kpb 与凯尔血型系统中抗原性减弱相关：第二个例子
作者：
ML Beck;W. Marsh;SR Pierce;J. DiNapoli;R. Oyen;ME Nichols
1例84岁女性肠道出血患者Kell系统中红细胞抗原性显著降低，自身抗Kpb导致直接抗球蛋白试验阳性。她的细胞的Kx抗原活性增加，这一观察结果支持Kx标志着正常Kell生物合成途径中使用的前体结构的信念。据推测，Kell抗原性降低是一种获得性变化，由酶降解引起，可能是细菌来源。
An 84‐year‐old woman with intestinal bleeding had marked reduction of red blood cell antigenicity in the Kell system, and a positive direct antiglobulin test caused by auto‐anti‐Kpb. Kx antigen activity of her cells was increased, an observation which supports the belief that Kx marks a precursor structure utilized in the normal Kell biosynthetic pathway. It is postulated that reduced Kell antigenicity was an acquired change that resulted from enzymatic degradation, possibly of bacterial origin.