The human gene for apurinic/apyrimidinic endonuclease (HAP1): sequence and localization to chromosome 14 band q12.
The human gene for apurinic/apyrimidinic endonuclease (HAP1): sequence and localization to chromosome 14 band q12.
复制标题
人类脱嘌呤/脱嘧啶核酸内切酶 (HAP1) 基因：序列和定位至 14 号染色体带 q12。
DOI：
10.1093/nar/20.15.4097
复制
发表时间：
1992
影响因子：
14.9
通讯作者：
Henner,WD
中科院分区：
文献类型：
--
作者：
Zhao,B;Grandy,DK;Hagerup,JM;Magenis,RE;Smith,L;Chauhan,BC;Henner,WD
Both bacterial and mammalian cells contain multiple forms of apurinic endonucleases, including both class II AP endonucleases and AP lyases. The cDNAs for the major Mg2+-dependent apurinic endonuclease of bovine (1), mouse (2) and human cells (3-5) have all recently been cloned and sequenced. The human cDNA has been variously designated HAPI (3) or APE (4). The deduced amino acid sequences of the bovine and human cDNAs are nearly identical and have homology to exonuclease HI of E. coli, exoA of S. pneumoniae and the Drosophila Rrpl protein. The HAPI protein is likely to be important in protection of cells against both spontaneous and induced DNA damages and mutagenesis and the gene coding for this protein could be involved in human diseases of DNA repair deficiency. We have cloned
