Inverse association between glucose variability and body fat in type 2 diabetes with impaired endogenous insulin secretion assessed using continuous glucose monitoring: A prospective observational study
Inverse association between glucose variability and body fat in type 2 diabetes with impaired endogenous insulin secretion assessed using continuous glucose monitoring: A prospective observational study
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DOI：
10.1111/dom.15049
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发表时间：
2023-03-31
影响因子：
5.8
通讯作者：
Atsumi，Tatsuya
中科院分区：
文献类型：
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作者：
Miya，Aika;Nakamura，Akinobu;Atsumi，Tatsuya
AimTo评估体脂肪质量和血清脂联素浓度的贡献葡萄糖变异性（GV）的稳定性在2型糖尿病与受损与保存内源性insulin secretion.Materials和methodsThis多中心前瞻性观察性研究包括193人与2型糖尿病谁进行动态连续血糖监测，腹部计算机断层扫描和空腹血液采样的人。空腹C肽（FCP）浓度>2 ng/mL定义为内源性胰岛素分泌保留。参与者被分为高（FCP > 2 ng/mL）和低FCP亚组（FCP ≤ 2 ng/mL）。结果在高FCP亚组中，GV的变异系数（CV）与腹部脂肪面积无关。在低FCP亚组中，高CV与小的腹部内脏脂肪面积（β =-0.11，标准误0.03;P< 0.05）和小的皮下脂肪面积（β =-0.09，标准误0.04;P< 0.05）显著相关。血清脂联素浓度与动态血糖监测相关变量之间无显著相关性。ConclusionsThe contribution of body fat mass to GV depends on the endogenous insulin secretion residue.在2型糖尿病和内源性胰岛素分泌受损的人群中，较小的体脂面积对GV有独立的不良影响。
AimTo evaluate the contribution of body fat mass and serum adiponectin concentration to glucose variability (GV) stability in people with type 2 diabetes with impaired versus preserved endogenous insulin secretion.Materials and methodsThis multicentre prospective observational study included 193 people with type 2 diabetes who underwent ambulatory continuous glucose monitoring, abdominal computed tomography and fasting blood sampling. A fasting C‐peptide (FCP) concentration >2 ng/mL was defined as preserved endogenous insulin secretion. The participants were divided into high (FCP > 2 ng/mL) and low FCP subgroups (FCP ≤ 2 ng/mL). Multivariate regression analysis was performed in each subgroup.ResultsIn the high FCP subgroup, the coefficient of variation (CV) in GV was unrelated to abdominal fat area. In the low FCP subgroup, a high CV was significantly related to small abdominal visceral fat area (β = –0.11, standard error 0.03;P< 0.05) and to small subcutaneous fat area (β = –0.09, standard error 0.04;P< 0.05). No significant relationship between serum adiponectin concentration and continuous glucose monitoring‐related variables was found.ConclusionsThe contribution of body fat mass to GV depends on the endogenous insulin secretion residue. A small body fat area has independent adverse effects on GV in people with type 2 diabetes and impaired endogenous insulin secretion.