Evolution of surgery in the treatment of hepatocellular carcinoma from the 1950s to the 1990s.
Evolution of surgery in the treatment of hepatocellular carcinoma from the 1950s to the 1990s.
复制标题
从 20 世纪 50 年代到 90 年代肝细胞癌手术治疗的演变。
DOI：
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发表时间：
1993
期刊：
影响因子：
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通讯作者：
X. Zhou
中科院分区：
文献类型：
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作者：
Z. Tang;Y. Yu;X. Zhou
在20世纪50年代，巨大肝细胞癌（HCC）的肝叶切除术使5-10%的HCC患者受益;在20世纪70年代，小HCC的有限切除和复发的再切除使另外5-10%的HCC患者受益。在20世纪90年代，对不能切除的HCC进行细胞减灭和序贯切除可能会使另外5-10%的HCC患者受益。对1959-1991年1,642例经病理证实的HCC患者的分析表明，系列5年生存率从20世纪60年代的3.0%（n = 136）增加到20世纪70年代的12.2%（n = 440），（n = 1，066），这与小HCC的有限切除、亚临床复发的再切除以及部分不可切除HCC的细胞减灭和序贯切除的数量增加相关。随着早期发现、多模式治疗和外科肿瘤学概念的改变，手术在HCC治疗中的作用有所增加。
In the 1950s, hepatic lobectomy for huge hepatocellular carcinoma (HCC) has benefited 5-10% of HCC patients; in the 1970s, limited resection for small HCC and reresection for recurrence have benefited another 5-10% HCC patients. Cytoreduction and sequential resection for unresectable HCC might be of benefit to a further 5-10% HCC patients in the 1990s. Analysis of 1,642 patients with pathologically proven HCC in 1959-1991 demonstrated that the series 5-year survival has increased from 3.0% (n = 136) in the 1960s, to 12.2% (n = 440) in the 1970s, to 40.2% (n = 1,066) in the 1980s, which was correlated to the increasing number of limited resections for small HCC, reresections for subclinical recurrence, and cytoreductions and sequential resections for portions of unresectable HCC. With the advances in early detection, multimodality treatment, and changing concepts in surgical oncology, the role of surgery in the treatment of HCC has increased.