Human papillomavirus in squamous cell carcinoma of esophagus in a high-risk population
Human papillomavirus in squamous cell carcinoma of esophagus in a high-risk population
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DOI：
10.3748/wjg.v11.i8.1200
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发表时间：
2005-02-28
影响因子：
4.3
通讯作者：
Malekzadeh, Reza
中科院分区：
文献类型：
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作者：
Farhadi, Mohammad;Tahmasebi, Zahra;Malekzadeh, Reza
目的：探讨伊朗人乳头瘤病毒（HPV）与食管鳞状细胞癌（ESCC）的关系。方法：使用MY09/MY11共识引物，我们比较了38例ESCC病例的肿瘤组织和38例内镜下正常伊朗人的活检组织中HPV L1基因的患病率。我们还使用类型特异性的E6/E7引物比较了相同样品中HPV16和HPV18的存在。结果：38例ESCC中14例（36.8%）HPV L1基因阳性，而38例对照中仅有5例（13.2%）HPV L1基因阳性（P = 0.02）。5例（13.2%）ESCC标本HPV16 E6/E7基因阳性，对照组无阳性（P = 0.05）。3份ESCC标本（7.9%）和5份对照标本（13.2%）HPV18 E6/E7基因阳性（P = 0.71）。结论：我们的数据与其他ESCC高危地区的HPV DNA研究一致。HPV应被认为是导致伊朗和世界其他高发地区ESCC高发的潜在因素。(C) 2005 WJG出版社和爱思唯尔公司。版权所有。
AIM: To investigate the relation of human papillomavirus (HPV) and esophageal squamous cell carcinoma (ESCC) in Iranian patients as compared to normal controls.METHODS: Using MY09/MY11 consensus primers, we compared the prevalence of a HPV L1 gene in tumor tissues from 38 ESCC cases and biopsied tissues from 38 endoscopically normal Iranian individuals. We also compared the presence of HPV16 and HPV18 in the same samples using type-specific E6/E7 primers.RESULTS: Fourteen (36.8%) of the 38 ESCC samples but only 5 (13.2%) of the 38 control samples were positive for the HPV L1 gene (P = 0.02). Five (13.2%) of the ESCC samples but none of the control samples were positive for the HPV16 E6/E7 gene (P = 0.05). Three (7.9%) of the ESCC samples and 5 (13.2%) of the control samples were positive for the HPV18 E6/E7 gene (P = 0.71).CONCLUSION: Our data are consistent with HPV DNA studies conducted in other high-risk areas for ESCC. HPV should be considered as a potential factor contributing to the high incidence of ESCC in Iran and other high-incidence areas of the world. (C) 2005 The WJG Press and Elsevier Inc. All rights reserved.