DIFFERENTIAL EXPRESSION OF GENES ENCODING TGFS BETA-1, BETA-2, AND BETA-3 DURING MURINE PALATE FORMATION
DIFFERENTIAL EXPRESSION OF GENES ENCODING TGFS BETA-1, BETA-2, AND BETA-3 DURING MURINE PALATE FORMATION
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DOI：
10.1016/0012-1606(90)90401-4
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发表时间：
1990-10-01
影响因子：
2.7
通讯作者：
MOSES, HL
中科院分区：
文献类型：
--
作者：
PELTON, RW;HOGAN, BLM;MOSES, HL
转化生长因子β1(TGF.beta1)已被证明对腭源性细胞类型的原代培养有多种影响。我们报道了通过原位杂交分析三种不同的TGF.β的RNA表达。小鼠胚胎腭部发育过程中的亚型(TGFβ1、β2和β3)。三种转化生长因子β的差异表达。已知参与该器官形态发生的基因存在于间充质细胞和上皮细胞的腭架上。综上所述，这些结果表明，TGF.beta.s作为内源性因子参与了哺乳动物味觉的形成。
Transforming growth factor .beta.1 (TGF.beta.1) has been shown to have multiple effects on primary cultures of palate-derived cell types. We report the analysis, by in situ hybridization, of RNA expression for three different TGF.beta. isoforms (TGF.beta.1, .beta.2, and .beta.3) during murine embryonic palate development. Differential expression of the three TGF.beta. genes is seen in the palatal shelves in mesenchymal and epithelial cells known to be involved in the morphogenesis of this organ. Taken together, these results suggest that the TGF.beta.s act as endogenous factors involved in the formation of the mammalian palate.