Posttraining handling facilitates memory for auditory-cue fear conditioning in rats
Posttraining handling facilitates memory for auditory-cue fear conditioning in rats
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DOI：
10.1016/j.nlm.2006.02.002
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发表时间：
2006-09-01
影响因子：
2.7
通讯作者：
Weinberger, Norman M.
中科院分区：
文献类型：
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作者：
Hui, Isabel R.;Hui, Gabriel K.;Weinberger, Norman M.
大量研究表明，学习经历后立即承受压力或服用应激激素和其他神经活性药物可以调节长期记忆的巩固。然而，对于通过处理动物以施用这些药物而引起的唤醒如何影响记忆的研究很少。因此，本研究检查了训练后注射或处理程序本身是否影响听觉线索经典恐惧条件反射的记忆。雄性 Sprague-Dawley 大鼠在调理前已预先处理了三天，每次 1 分钟，接受三对单频听觉刺激和足部电击，然后立即皮下注射载体溶液或在不注射的情况下进行短暂处理。对照组被放回自己的笼子里，没有接受任何训练后处理。 24 小时后，在一个新的房间中测试了记忆力，并在 10 秒的听觉提示呈现期间抑制持续的运动行为，作为条件性恐惧的衡量标准。接受训练后注射或处理的动物彼此之间没有差异，但与未处理的对照组相比，刺激引起的运动显着减少。因此，这些发现表明，训练后注射或处理程序足以引起或产生压力，以促进听觉线索经典恐惧条件反射的记忆巩固。 (c) 2006 Elsevier Inc. 保留所有权利。
A large number of studies have indicated that stress exposure or the administration of stress hormones and other neuroactive drugs immediately after a learning experience modulates the consolidation of long-term memory. However, there has been little investigation into how arousal induced by handling of the animals in order to administer these drugs affects memory. Therefore, the present study examined whether the posttraining injection or handling procedure per se affects memory of auditory-cue classical fear conditioning. Male Sprague-Dawley rats, which had been pre-handled on three days for 1 min each prior to conditioning, received three pairings of a single-frequency auditory stimulus and footshock, followed immediately by either a subcutaneous injection of a vehicle solution or brief handling without injection. A control group was placed back into their home cages without receiving any posttraining treatment. Retention was tested 24 h later in a novel chamber and suppression of ongoing motor behavior during a 10-s presentation of the auditory-cue served as the measure of conditioned fear. Animals that received posttraining injection or handling did not differ from each other but showed significantly less stimulus-induced movement compared to the non-handled control group. These findings thus indicate that the posttraining injection or handling procedure is sufficiently arousing or stressful to facilitate memory consolidation of auditory-cue classical fear conditioning. (c) 2006 Elsevier Inc. All rights reserved.