Neurotrophins and schizophrenia
Neurotrophins and schizophrenia
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DOI：
10.1016/j.schres.2007.01.025
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发表时间：
2007-08-01
影响因子：
4.5
通讯作者：
Terry, Alvin, Jr.
中科院分区：
文献类型：
--
作者：
Buckley, Peter F.;Mahadik, Sahebarao;Terry, Alvin, Jr.
神经营养因子在神经元发育、突触发生和对应激/焦虑刺激的反应中具有确定的作用。此外，这些药物是单胺能、GABA能和胆碱能系统的神经调节剂。随着人们对精神分裂症的发育神经生物学以及进行性大脑变化倾向的认识不断提高，出现了精神分裂症神经营养因子表达异常的信息。本文综述了神经营养因子与精神分裂症的相关文献。提供了一个理解精神分裂症复发的神经生物学的模式。(C)2007年由Elsevier B. V.出版。
Neurotrophins have established roles in neuronal development, synaptogenesis, and response to stress/anxious stimuli. Moreover, these agents are neuromodulators of monoaminergic, GABAergic, and cholinergic systems. Amidst a growing appreciation of the developmental neurobiology of schizophrenia - as well as the propensity for progressive brain changes - there is emergent information on abnormalities in the expression of neurotrophins in schizophrenia. This article reviews the literature on neurotrophins and schizophrenia. A schema for understanding the neurobiology of relapse in schizophrenia is offered. (C) 2007 Published by Elsevier B.V.