Body size, insulin/IGF signaling and aging in the nematode Caenorhabditis elegans
Body size, insulin/IGF signaling and aging in the nematode Caenorhabditis elegans
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DOI：
10.1016/s0531-5565(02)00147-x
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发表时间：
2003-01-01
影响因子：
3.9
通讯作者：
Gems, D
中科院分区：
文献类型：
--
作者：
McCulloch, D;Gems, D
最近对果蝇、老鼠和狗的衰老研究表明，体型缩小与寿命延长之间存在联系。目前尚不清楚（a）这种关联是否是动物物种的一般特征;（B）这种关联是否反映了身体大小对衰老的影响，或生长和衰老的共同决定因素的多效性效应。为了解决这些问题，我们研究了线虫的大小和寿命之间的关系，并调查了果蝇的相关发现。In C.我们比较了12个具有不同体型和寿命的野生分离株，但发现这些特征之间没有对应关系。我们还研究了巨人和侏儒突变体的衰老，但在所有情况下都只观察到寿命缩短。在对15种长寿的daf-2胰岛素/IGF受体突变体进行比较时，我们发现体长与寿命之间存在正相关性，并且daf-2突变体的身体体积增加了28%。因此，在C.对于线虫，胰岛素/IGF信号可能限制而不是促进生长。对果蝇的研究表明，身体大小和寿命之间没有一致的相关性。这些结果表明，在一些哺乳动物中观察到的身体大小和寿命之间的负相关性在无脊椎动物中并不典型，但支持这样的观点，即大小和寿命的共同变化可能通过对胰岛素/IGF信号的影响而发生。(C)2002年爱思唯尔科学公司All rights reserved.
A number of recent studies of aging in Drosophila, mice and dogs have shown an association between reduced body size and increased lifespan. It is unclear (a) whether such an association is a general feature of animal species; and (b) whether the association reflects an effect of body size on aging, or pleiotropic effects of common determinants of growth and aging. To address these issues, we have studied the relationship between size and lifespan in the nematode Caenorhabditis elegans, and surveyed related findings in Drosophila. In C. elegans, we compared 12 wild isolates with varying body size and lifespan, but saw no correspondence between these traits. We also examined aging in giant and dwarf mutants, but observed only reduced lifespan in all cases. In a comparison of 15 long-lived daf-2 insulin/IGF receptor mutants, we saw a positive correlation between body length and lifespan, and up to a 28% increase in daf-2 mutant body volume. Thus, in C. elegans, insulin/IGF signaling may limit growth rather than promote it. Studies of Drosophila show no consistent correlation between body size and lifespan. These results indicate that the negative correlation between body size and lifespan seen in some mammals is not typical of invertebrates, but support the view that co-variation of size and longevity may occur via effects on insulin/IGF signaling. (C) 2002 Elsevier Science Inc. All rights reserved.