Clonal spread in Eastern Asia of ciprofloxacin-resistant Escherichia coli serogroup O25 strains, and associated virulence factors
Clonal spread in Eastern Asia of ciprofloxacin-resistant Escherichia coli serogroup O25 strains, and associated virulence factors
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DOI：
10.1016/j.ijantimicag.2009.12.012
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发表时间：
2010-05-01
影响因子：
10.8
通讯作者：
Kang, Dongchon
中科院分区：
文献类型：
--
作者：
Uchida, Yujiro;Mochimaru, Tomomi;Kang, Dongchon
感染性疾病领域的一个重要问题是耐氟喹诺酮（FQ）大肠杆菌的增加。虽然菌株的突变和克隆传播被认为是这种增加的原因，但对这种生物的流行知之甚少。对219株耐药大肠杆菌进行了检测。大肠杆菌菌株的血清分型和基因分型。O25血清群71株（32.4%），主要分布在韩国、中国和日本，尤其是日本西南部。产气杆菌素是泌尿系和禽类致病性大肠杆菌的毒力因子。大肠埃希菌O25耐药株的存在与大肠埃希菌O25耐药株的存在有关。杆菌在71株耐药大肠杆菌中，有7株耐药大肠杆菌。大肠杆菌O25具有超广谱β-内酰胺酶基因（6个CTX-M-14和1个SHV-12），然而，我们无法找到任何大肠杆菌。大肠杆菌O25-ST 131克隆，产生CTX-M-15，这是以前报道已经出现在各大洲。这些数据表明，一个克隆组的抗大肠杆菌和毒力。大肠杆菌最近至少在东亚流行，这表明这可能成为一个公共卫生问题，因为这些菌株可能对其他抗菌药物产生耐药性。(C)2010年爱思唯尔B。和国际化疗学会。All rights reserved.
A significant problem in the field of infectious diseases is the increase in fluoroquinolone (FQ)-resistant Escherichia coli. Although mutation of strains and clonal dissemination are supposed to be the cause of this increase, little is known about the prevalence of this organism. We investigated 219 FQ-resistant E. coli strains in Japan and nine Asian countries by serotyping and genotyping. Seventy-one strains (32.4%) were serogroup O25, which was prevalent in South Korea, China and Japan, especially in the southwest part of Japan. Aerobactin, a virulence factor in uropathogenic and avian pathogenic E. coli, was associated with the presence of FQ-resistant O25 strains of E. coli. Seven of the seventy-one FQ-resistant E. coli O25 had extended-spectrum beta-lactamase genes (six CTX-M-14 and one SHV-12), however, we were unable to find any E. coli O25-ST131 clone that produced CTX-M-15, which was previously reported to have emerged across continents. These data demonstrate that a clonal group of FQ-resistant and virulent E. coli recently became prevalent at least in East Asia and suggest that this might become a public health problem because the strains may acquire resistance to other antimicrobial agents. (C) 2010 Elsevier B. V. and the International Society of Chemotherapy. All rights reserved.