Socioeconomic status, antioxidant micronutrients, and correlates of oxidative damage: the Coronary Artery Risk Development in Young Adults (CARDIA) study.
Socioeconomic status, antioxidant micronutrients, and correlates of oxidative damage: the Coronary Artery Risk Development in Young Adults (CARDIA) study.
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DOI：
10.1097/psy.0b013e31819e7526
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发表时间：
2009-06
影响因子：
3.3
通讯作者：
Jacobs DR Jr
中科院分区：
文献类型：
--
作者：
Janicki-Deverts D;Cohen S;Matthews KA;Gross MD;Jacobs DR Jr
患慢性病的风险随着社会经济地位（SES）的降低而增加。低社会经济地位可能影响疾病风险的一个途径是促进氧化应激。本研究的目的是研究SES（教育、职业、收入）是否与(a)两种氧化损伤相关因子f2 -异前列腺素（F2-IsoPs）和γ -谷氨酰转移酶（GGT）的循环浓度横切面和前瞻性相关；(b)抗氧化营养素（抗坏血酸和类胡萝卜素）。我们还研究了所提出的关联是否由吸烟、饮酒和抑郁介导。来自1278名年轻人冠状动脉风险发展（CARDIA）研究参与者的数据被用来研究SES与氧化相关物质和抗氧化营养素的关系。在研究的第0年、第10年和第15年评估教育、职业、健康行为和身体质量指数（BMI）；10年级和15年级的收入和抑郁。在第15年测量F2-IsoPs，在第0年和第10年测量GGT，在第0年和第15年测量类胡萝卜素，在第10年和第15年测量抗坏血酸。从横截面上看，随着社会经济地位的增加，氧化相关性降低，抗氧化营养素增加，这与年龄、性别、种族和BMI无关。前瞻性地，较低的0年级教育和职业预示着10-15年内GGT的增加和类胡萝卜素的减少。0年级SES与15年级类胡萝卜素的预期关联独立于15年级SES。吸烟、饮酒和抑郁症状部分介导了这些影响。随着SES的降低，循环氧化与抗氧化营养素的增加和减少相关。
Risk for chronic disease increases with decreasing socioeconomic status (SES). One pathway by which low SES might influence disease risk is by promoting oxidative stress. The aim of the present study is to examine whether SES (education, occupation, income), is associated both cross-sectionally and prospectively with circulating concentrations of (a) two correlates of oxidative damage, F2-isoprostanes (F2-IsoPs) and gamma-glutamyltransferase (GGT); and (b) antioxidant nutrients (ascorbic acid and carotenoids). We also examine whether the proposed associations are mediated by smoking, alcohol consumption and depression. Data from 1278 participants in the Coronary Artery Risk Development in Young Adults (CARDIA) study were used to examine the association of SES with oxidation correlates and antioxidant nutrients. Education, occupation, health behaviors, and body mass index (BMI) were assessed during Years 0, 10, and 15 of the study; income and depression at Years 10 and 15. F2-IsoPs were measured at Year 15, GGT at Years 0 and 10, carotenoids at Years 0 and 15, and ascorbic acid at Years 10 and 15. Cross-sectionally, oxidation correlates decreased and antioxidant nutrients increased with increasing SES, estimated in several ways, independent of age, sex, race, and BMI. Prospectively, lower Year 0 education and occupation predicted greater increases in GGT and greater decreases in carotenoids over 10–15 years. Prospective associations of Year 0 SES with Year 15 carotenoids were independent of Year 15 SES. Smoking, drinking, and depression symptoms partially mediated these effects. Circulating oxidation correlates increase and antioxidant nutrients decrease with decreasing SES, both cross-sectionally and prospectively.