Antibodies against GPCR
Antibodies against GPCR
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DOI：
10.2741/4698
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发表时间：
2018-06-01
影响因子：
3.1
通讯作者：
Heidecke, Harald
中科院分区：
文献类型：
--
作者：
Meyer, Carlotta;Heidecke, Harald
G蛋白偶联受体（GPCR）是人类最大的受体家族。 GPCR 是七次跨膜受体，通过配体与胞外结构域的结合而被激活。除了内源性配体外，自身抗体 (aab) 也可以与 GPCR 结合。它们可以激活导致各种疾病的不同且特定的细胞途径。在这篇综述中，作者总结了有关针对 GPCR 的抗体及其在各种疾病发病机制中的作用和相关性及其在临床诊断中的应用的知识。我们强调不同的激活性抗-GPCR aab 在实体器官移植、干细胞移植、系统性硬化症、先兆子痫、慢性疲劳综合征、心血管疾病、阿尔茨海默病和癌症中的作用。
G-protein-coupled receptors (GPCRs) are the largest family of receptors in humans. GPCRs are seven-transmembrane receptors that are activated by the binding of a ligand to the extracellular domain. In addition to the endogenous ligands, auto-antibodies (aab) can also bind to the GPCRs. They can activate different and specific cellular pathways which contribute to various diseases. In this review, the authors summarize the knowledge about antibodies targeting GPCRs and their effects and relevance in the pathogenesis of various diseases and their use in clinical diagnostics. We highlight the role of different activating anti-GPCR aab in solid organ transplantations, stem cell transplantations, systemic sclerosis, preeclampsia, chronic fatigue syndrome, cardiovascular diseases, Alzheimer's disease, and cancer.