Deficits in stepping response time are associated with impairments in balance and mobility in people with Huntington disease.
Deficits in stepping response time are associated with impairments in balance and mobility in people with Huntington disease.
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DOI：
10.1016/j.jns.2010.08.002
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发表时间：
2010-11-15
影响因子：
4.4
通讯作者：
Conti, Gerry E.
中科院分区：
文献类型：
--
作者：
Goldberg, Allon;Schepens, Stacey L.;Feely, Shawna M. E.;Garbern, James Y.;Miller, Lindsey J.;Siskind, Carly E.;Conti, Gerry E.
亨廷顿病（HD）是一种以舞蹈病、肌张力障碍、运动迟缓、认知能力下降和精神合并症为特征的疾病。平衡和步态障碍以及跌倒是该疾病的常见表现。补偿性快速步进对维持老年人平衡的重要性已得到证实，但对于步进反应时间（SRTs）在HD患者平衡控制中的作用知之甚少。在大学活动研究实验室，对14名有症状的HD患者和9名对照组进行了srt和常用的临床平衡和活动测量。在HD参与者中量化了相对和绝对可靠性，以及SRT的最小可检测变化。与对照组相比，HD参与者表现出较慢的srt和较差的动态平衡、机动性和运动表现。HD参与者也报告了比对照组更低的平衡信心。在HD参与者中，SRT的缺陷与平衡信心低和平衡、活动能力和运动表现的临床测量障碍有关。相对可靠性和绝对可靠性的测量表明，在HD患者的试验中，SRT是可靠的和可重复的。适度低百分比的最小可检测变化表明SRT对检测HD患者的真正变化很敏感。SRT在HD患者中受损，可能是疾病进展的有效和客观标志。
Huntington disease (HD) is a disorder characterized by chorea, dystonia, bradykinesia, cognitive decline and psychiatric comorbidities. Balance and gait impairments, as well as falls, are common manifestations of the disease. The importance of compensatory rapid stepping to maintain equilibrium in older adults is established, yet little is known of the role of stepping response times (SRTs) in balance control in people with HD. SRTs and commonly-used clinical measures of balance and mobility were evaluated in fourteen symptomatic participants with HD, and nine controls at a university mobility research laboratory. Relative and absolute reliability, as well as minimal detectable change in SRT were quantified in the HD participants. HD participants exhibited slower SRTs and poorer dynamic balance, mobility and motor performance than controls. HD participants also reported lower balance confidence than controls. Deficits in SRT were associated with low balance confidence and impairments on clinical measures of balance, mobility, and motor performance in HD participants. Measures of relative and absolute reliability indicate that SRT is reliable and reproducible across trials in people with HD. A moderately low percent minimal detectable change suggests that SRT appears sensitive to detecting real change in people with HD. SRT is impaired in people with HD and may be a valid and objective marker of disease progression.
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影响因子：
9.9
作者：
Wheelock, VL;Tempkin, T;Shoulson, I
通讯作者：
Shoulson, I
DOI：
10.1093/gerona/51a.6.m289
发表时间：
1996-11-01
影响因子：
5.1
作者：
McIlroy, WE;Maki, BE
通讯作者：
Maki, BE
影响因子：
3.2
作者：
Haley, SM;Fragala-Pinkham, MA
通讯作者：
Fragala-Pinkham, MA
DOI：
10.1093/gerona/55.8.m429
发表时间：
2000-08-01
影响因子：
5.1
作者：
Medell, JL;Alexander, NB
通讯作者：
Alexander, NB
影响因子：
2.4
作者：
Delval, A.;Krystkowiak, P.;Defebvre, L.
通讯作者：
Defebvre, L.