Endothelin-1 and its role in the pathogenesis of infectious diseases.
Endothelin-1 and its role in the pathogenesis of infectious diseases.
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DOI：
10.1016/j.lfs.2014.04.021
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发表时间：
2014-11-24
期刊：
影响因子：
6.1
通讯作者：
Desruisseaux MS
中科院分区：
文献类型：
--
作者：
Freeman BD;Machado FS;Tanowitz HB;Desruisseaux MS
内皮素是血管张力的有效调节剂，其还具有促有丝分裂、凋亡和免疫调节特性。迄今为止，已经鉴定了内皮素的三种亚型，其中内皮素-1（ET-1）是研究得最好的。ET-1被认为是一种有效的血管收缩剂。然而，除了ET-1对血管平滑肌细胞的作用外，该肽越来越被认为是促炎细胞因子。ET-1引起血小板聚集，并在白细胞粘附分子表达增加中起作用，白细胞粘附分子是导致血管功能障碍的炎性介质的合成。在肺泡巨噬细胞、白细胞和成纤维细胞中发现高水平的ET-1。临床和实验数据表明，ET-1参与脓毒症、病毒性和细菌性肺炎、康氏立克次体感染、恰加斯病和严重疟疾的发病机制。在这篇小综述中，我们将讨论内皮素在感染过程的发病机制中的作用。
Endothelins are potent regulators of vascular tone, which also have mitogenic, apoptotic, and immunomodulatory properties. Three isoforms of endothelin have been identified to date, with endothelin-1 (ET-1) being the best studied. ET-1 is classically considered a potent vasoconstrictor. However, in addition to the effects of ET-1 on vascular smooth muscle cells, the peptide is increasingly recognized as a pro-inflammatory cytokine. ET-1 causes platelet aggregation and plays a role in the increased expression of leukocyte adhesion molecules, the synthesis of inflammatory mediators contributing to vascular dysfunction. High levels of ET-1 are found in alveolar macrophages, leukocytes and fibroblasts. Clinical and experimental data indicate that ET-1 is involved in the pathogenesis of sepsis, viral and bacterial pneumonia, Rickettsia conorii infections, Chagas disease, and severe malaria. In this minireview, we will discuss the role of endothelin in the pathogenesis of infectious processes.