Use of magnetic resonance imaging for in vivo measurements of water content in human brain: method and normal values
Use of magnetic resonance imaging for in vivo measurements of water content in human brain: method and normal values
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DOI：
10.3171/jns.1999.90.1.0109
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发表时间：
1999-01-01
影响因子：
4.1
通讯作者：
Marmarou, A
中科院分区：
文献类型：
--
作者：
Fatouros, PP;Marmarou, A
对象。作者提出了一种定量体内磁共振成像方法，并提出了将其用于准确评估人类脑水的方法。使用该技术，生成患者选定的脑切片的纯t -1加权图像，然后通过从组织松弛模型导出的方程将图像转换为纯水图像。由此产生的水图中的图像强度直接产生在给定解剖位置以每克组织的水克数表示的水的绝对测量。该方法已经在之前的一系列幻体实验和猫脑水肿的输注模型中得到验证。在本报告中，作者通过使用从接受脑肿瘤切除手术的患者身上采集的组织样本来评估该方法，并将该技术应用于一系列正常志愿者，提供一系列组织的平均区域脑含水量（f(w)）值。该方法在脑外伤、肿瘤和脑积水等病理情况下的应用，可以量化水肿引起的局部或全局f(w)增加。现在有可能通过磁共振成像的解剖分辨率获得准确的脑水测量。这允许在各种临床情况下监测水肿的发展和消退，从而加强对潜在病理生理过程的理解。
Object. The authors present a quantitative in vivo magnetic resonance (MR) imaging method and propose its use for the accurate assessment of brain water in humans.Methods. With this technique, a pure T-1-weighted image of a selected brain slice in a patient is generated, and the image is subsequently converted to a pure water image by means of an equation derived from a tissue relaxation model. The image intensity in the resulting water map directly yields absolute measures of water expressed in grams of water per gram of tissue at a given anatomical location. The method has been validated previously in a series of phantom experiments and in an infusion model of brain edema in cats. In this report, the authors evaluate the method by using samples of tissue harvested from patients who underwent surgery for brain tumor removal and apply the technique to a series of normal volunteers, providing average regional brain water content (f(w)) values for a range of tissues. Application of the method in pathological conditions such as head trauma, tumor, and hydrocephalus allows quantification of regional or global increases in f(w) that result from edema.Conclusions. It is now possible to obtain accurate brain water measurements with the anatomical resolution of MR imaging. This permits monitoring of the development and resolution of edema in a variety of clinical circumstances, thus enhancing understanding of the underlying pathophysiological processes.