Time-dependent actions of D2 family agonist quinpirole on spontaneous behavior in the rat:: dissociation between sniffing and locomotion
Time-dependent actions of D2 family agonist quinpirole on spontaneous behavior in the rat:: dissociation between sniffing and locomotion
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DOI：
10.1007/s002130000677
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发表时间：
2001-04-01
影响因子：
3.4
通讯作者：
Joy, R
中科院分区：
文献类型：
--
作者：
Horvitz, JC;Williams, G;Joy, R
原理：多巴胺激动剂提高运动，嗅，梳理，和其他一些行为。然而，D1家族（D，ID，ID，）激动剂喹吡罗在宽剂量范围内产生一段时间的运动抑制，其先于药物的运动兴奋作用。目的：本研究询问quinpirole的抑制作用是否也延伸到自发行为的其他方面，例如嗅闻，饲养和梳理，或者这种运动抑制是否发生，而其他行为的频率增加或不受影响。研究方法：在接受0、0.1、0.5、1.0或10.0 mg/kg喹吡罗给药的大鼠中，在I50 min试验期内观察到运动、嗅闻、直立和梳理。结果：在0.1 mg/kg时，喹吡罗抑制运动。较高剂量（0.5-10.0 mg/kg）产生运动抑制，随后产生运动兴奋。在运动抑制期间，quinpirole也减少了直立和梳理的频率。然而，高剂量（1和10毫克/公斤）的喹吡罗下的动物表现出在运动，后方和新郎抑制期间的嗅闻升高。结论：这些结果表明，在主动嗅闻过程中，在喹吡罗的兴奋性运动行为之前发生了有据可查的运动抑制。这些结果表明，喹吡罗对运动的抑制作用并不反映一般行为抑制的状态。
Rationale: Dopamine agonists elevate locomotion, sniffing, grooming, and a number of other behaviors. However, the D, family (D,ID,ID,) agonist quinpirole, across a wide dose range, produces a period of locomotor inhibition that precedes the drug's locomotor excitatory effects. Objectives: The present study asked whether the suppressive actions of quinpirole also extend to other aspects of spontaneous behavior, such as sniffing, rearing and grooming, or whether this suppression of locomotion occurs while the frequency of other behaviors is increased or unaffected. Methods: Locomotion sniffing rearing and grooming were observed over a I50-min test session in rats treated with O, 0.1, 0.5, 1.0, or 10.0 mg/kg quinpirole. Results: At 0.1 mg/kg, quinpirole suppressed locomotion. Higher doses (0.5-10.0 mg/kg) produced locomotor suppression followed by locomotor excitation. During the period of locomotor suppression, quinpirole also reduced the frequency of rearing and grooming. However, animals under high doses (1 and 10 mg/kg) of quinpirole showed elevated sniffing during the period of locomotor, rear and groom suppression. Conclusions: These results demonstrate that the welldocumented locomotor suppression that precedes quinpirole's excitatory locomotor actions occurs in the midst of active sniffing. These results suggest that the suppressive effects of quinpirole on locomotion do not reflect a state of general behavioral suppression.